Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 400-830-7 | CAS number: 104810-48-2 EVERSORB 80; TINUVIN 1130; TINUVIN 213
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The skin sensitising potential of the test article was assessed in a study conducted according to OECD guideline 406 (1981, GPMT, Ciba-Geigy Ltd 1984f). Induction was performed intradermally (1% in sesame oil) and one week later epicutaneously (10% in Vaseline, 48 h, occlusive). Two weeks after epidermal induction animals were challenged epicutaneously for 24 h with 1% test substance in Vaseline and Vaseline alone under semi-occlusive conditions. Under the experimental conditions employed, 70% (14/20) and 50% (10/20) of animals exhibited a positive skin reaction 24 and 48 hours after challenge, respectively.
Criteria for inclusion in GHS category 1A are a positive response in the GPMT in more than 60% of the guinea pigs at an intradermal induction dose of <= 1% .
Migrated from Short description of key information:
A valid study on skin sensitization with the test substance is available. In a study conducted according to OECD guideline 406 (GPMT) a positive skin reaction was observed in 14/20 animals after 24 h (guinea pig, Ciba-Geigy Ltd 1984f) and 10/20 animals after 48 h.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance was classified for skin sensitization (Xi; R43) under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC
(Annex I index no. 607 -176 -00 -3).
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. More than 60% of the animals showed a resonse at an intradermal induction dose of 1%. As a result the substance is considered to be classified for skin sensitization in Category 1A under Regulation (EC) No. 1272/2008, as amended for the second time in Directive (EC 286/2011).
At the time the substance was included in table 3.1 of Annex VI (EC 1272/2008) no distinction was made between category 1A and 1B. The legal classification (Annex I index no. 607 -176 -00 -3)
is Skin Category 1 (H317).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
