Registration Dossier
Registration Dossier
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EC number: 226-024-3 | CAS number: 5223-06-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: publication
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available - Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Registry of Toxic Effects of Chemical Substances (RTECS®)
- Author:
- Canadian Centre for Occupational Health and Safety
- Bibliographic source:
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum,1986 Volume (issue)/page/year: -,847,1986
Materials and methods
- Principles of method if other than guideline:
- Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-ethylpyridine-2-ethanol
- EC Number:
- 226-024-3
- EC Name:
- 5-ethylpyridine-2-ethanol
- Cas Number:
- 5223-06-3
- Molecular formula:
- C9H13NO
- IUPAC Name:
- 2-(5-ethylpyridin-2-yl)ethan-1-ol
- Test material form:
- not specified
- Details on test material:
- RTECS Number : UT3150000
Chemical Name : Pyridine, 5-ethyl-2-hydroxyethyl-
CAS Registry Number : 5223-06-3
Synonyms/Trade Names : 5-Ethyl-2-hydroxyethylpyridine ; 2-Hydroxyethyl-5-ethylpyridine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No details available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied : 2 mg/24H - Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- - Standard Draize test
- Administration into the eye
Results and discussion
In vivo
- Irritant / corrosive response data:
- Reaction severity : Severe
Applicant's summary and conclusion
- Executive summary:
As a result of a standard Draize-Test on rabbits with a dose of 2 mg/24h a reaction severity "severe" is reported.
Reference : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume (issue)/page/year: -,847,1986
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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