Registration Dossier
Registration Dossier
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EC number: 204-593-9 | CAS number: 123-03-5
Endpoint summary
Administrative data
Description of key information
The oral LD50 of CPC is 560 mg/kg bw, and the inhalation LC50 is between 0.054 and 0.51 mg/L or 54 to 510 mg/m3. The dermal LD50 is greater than 5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 560.3 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 54 mg/m³ air
- Quality of whole database:
- adequate
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- adequate
Additional information
The oral LD50 of CPC is estimated in an Up-And-Down procedure in rats to be 560.3 mg/kg bw, with lethality observed when doses of 950 mg/kg bw are administered to rats. The inhalation LC50 in rats is between 0.054 and 0.51 mg/L, equivalent to 54 and 510 mg/m3. The dermal LD50 is greater than 5000 mg/kg bw in rats.
Justification for selection of acute toxicity – oral endpoint
experimental result
Justification for selection of acute toxicity – inhalation endpoint
experimental result
Justification for selection of acute toxicity – dermal endpoint
experimental result
Justification for classification or non-classification
The substance is classified for oral and inhalation toxicity according to Regulation EC No. 1272/2008. The oral LD50 of 560.3 mg/kg bw meets the criteria of Acute Toxicity, Category 4 (300 < LD50 < 2000 mg/kg bw). The acute inhalation LC50 is between 0.05 and 0.50 mg/L for dusts/mists, and so classified as Category 2. The substance is not classified for acute dermal toxicity, as the LD50 > 5000 mg/kg bw.
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