Registration Dossier
Registration Dossier
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EC number: 811-460-4 | CAS number: 53606-41-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants)
- Principles of method if other than guideline:
- Chenge of technique application of the test substance - the open chamber method was used. The test substance suspension (20 % concentration) was applied in quantities enough to completely cover the cornea. This change is deviation from study plan and had no impact on the results of the study.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-methoxy-5-nitrophenyl acetate
- Cas Number:
- 53606-41-0
- Molecular formula:
- C9H9NO5
- IUPAC Name:
- 2-methoxy-5-nitrophenyl acetate
- Reference substance name:
- 536-41-0
- IUPAC Name:
- 536-41-0
- Test material form:
- solid - liquid: suspension
- Details on test material:
- - Name of test material (as cited in study report): 2-methpoxy-5-nitrophenyl acetate
- Physical state: solid powder
- Analytical purity: 95 % w/w
- Lot/batch No.: 102014
- Expiration date of the lot/batch: unlisted
- Stability under test conditions: unlisted
- Storage condition of test material: Store in dry place, in dark in closed container at the room temperature
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- other: bovine eyes
Results and discussion
In vivo
Results
- Irritation parameter:
- other: In Vitro Irritancy Score (IVIS)
- Basis:
- mean
- Time point:
- other: -
- Score:
- 44.59
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Limit value for IVIS is 55.1 - larger value means positive response.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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