Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: expert statement
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Direct toxicokinetic data are not available on the test item. Certain physico-chemical properties suggest potential absorption at a limited level. The two repeated dose oral administration studies resulted in some microscopic changes in liver and kidney in rats treated with 50 or 120 mg/kg bw/day. Recovery was evident after treatment was stopped. These biological effects provide qualitative evidence that in rats at least, intestinal absorption, and subsequent tissue distribution, cellular uptake and biological effects of the test item or its metabolites take place.
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