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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient data available for assessment

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth, H.F. et al.,
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Ass. J. 23, 95-107

Materials and methods

Principles of method if other than guideline:
Single oral application of undiluted different dosesof test substance were given to male rats by gavage.Observation time 14 days
GLP compliance:
no
Test type:
other: acute oral toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohex-3-ene-1-carbaldehyde
EC Number:
202-858-3
EC Name:
Cyclohex-3-ene-1-carbaldehyde
Cas Number:
100-50-5
Molecular formula:
C7H10O
IUPAC Name:
cyclohex-3-ene-1-carbaldehyde
Details on test material:
4-Cyclohexene-1-carboxaldehyde ( no further data)

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: no
- Housing: no data
- Diet ad libitum
- Water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
standard method (details not given)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
the dosages are arranged in a logaithmic series differing by a factor of 2 (no further details)
No. of animals per sex per dose:
5 males per dose group
Control animals:
no
Details on study design:
Single oral application of undiluted different doses of test substance were given to nonfasted male rats by gavage.Observation time 14 days
Statistics:
LD50 was estimated by the method of Thompson (1947) Bacteriol Rev 11, 115 using the tables of Weil (1952) Biometrics 8, 249

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 379 mg/kg bw
Based on:
test mat.
95% CL:
>= 1 880 - <= 3 230

Any other information on results incl. tables

original value: 2.46 ml/kg; density: 0.967 g/cm3

Applicant's summary and conclusion

Executive summary:

LD50 rat: 2379 mg/kg