Registration Dossier
Registration Dossier
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EC number: 202-858-3 | CAS number: 100-50-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient data available for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth, H.F. et al.,
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Ass. J. 23, 95-107
Materials and methods
- Principles of method if other than guideline:
- Single oral application of undiluted different dosesof test substance were given to male rats by gavage.Observation time 14 days
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
Test material
- Reference substance name:
- Cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 202-858-3
- EC Name:
- Cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 100-50-5
- Molecular formula:
- C7H10O
- IUPAC Name:
- cyclohex-3-ene-1-carbaldehyde
- Details on test material:
- 4-Cyclohexene-1-carboxaldehyde ( no further data)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: no
- Housing: no data
- Diet ad libitum
- Water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
standard method (details not given)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- the dosages are arranged in a logaithmic series differing by a factor of 2 (no further details)
- No. of animals per sex per dose:
- 5 males per dose group
- Control animals:
- no
- Details on study design:
- Single oral application of undiluted different doses of test substance were given to nonfasted male rats by gavage.Observation time 14 days
- Statistics:
- LD50 was estimated by the method of Thompson (1947) Bacteriol Rev 11, 115 using the tables of Weil (1952) Biometrics 8, 249
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 379 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 880 - <= 3 230
Any other information on results incl. tables
original value: 2.46 ml/kg; density: 0.967 g/cm3
Applicant's summary and conclusion
- Executive summary:
LD50 rat: 2379 mg/kg
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