Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-858-3 | CAS number: 100-50-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- other: microfiche
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
- Principles of method if other than guideline:
- other: acute inhalation study
- GLP compliance:
- not specified
- Test type:
- other: acute inhalation study
Test material
- Reference substance name:
- Cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 202-858-3
- EC Name:
- Cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 100-50-5
- Molecular formula:
- C7H10O
- IUPAC Name:
- cyclohex-3-ene-1-carbaldehyde
- Details on test material:
- 1,2,3,6-tetrahydrobenzaldehyde (THBA), purity:>99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gas chromatograph
- Duration of exposure:
- 4 - 8 h
- Remarks on duration:
- four experiments: time points: 4h, 6h and 8 h
- Concentrations:
- experiment I: 6 h exposure: 1679 ppm, experiment II: 8 h exposure: 1437 ppm, experiment III: 6 h exposure: 1939 ppm, experiment IV: 4h exposure: 1571 ppm
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: LT50 value
- Effect level:
- 5.66 other: hours
- Based on:
- test mat.
- Remarks on result:
- other: LT50 value: static group 8 and 4 hours groups
- Sex:
- male/female
- Dose descriptor:
- other: dynamic exposure group
- Effect level:
- 1 679 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: clinical signs
- Sex:
- male/female
- Dose descriptor:
- other: static condtions
- Effect level:
- 1 571 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: clinical signs
- Sex:
- male/female
- Dose descriptor:
- other: static group
- Effect level:
- 1 939 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: clinical signs, macroscopic lesions, death 10/10
- Sex:
- male/female
- Dose descriptor:
- other: static group
- Effect level:
- 1 437
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: clinical signs, macroscopic lesions, death 10/10
Any other information on results incl. tables
Dynamic exposure group(6 h, 1679 ppm):
Clinical signs: day of exposure: blepharospasm, lacrimation, severe periocular encrustation, perinasal wetness/encrustation, hypoactivity, mouth breathing and audible respiration
postexposure period: periocular encrustation, unkempt fur, and hypoactivity on the day following exposure
Mortaility: no rat died during exposure or during the 14 -day postexposure period
Body weights: mean body weight gain was observed for both sexes at 7 and 14 days following the day of exposure
Necropsy: No macroscopic lesions were observed in animals sacrificed at the end of the 2 -week post-exposure period
Static exposure (4h 1571 ppm, 6 h 1939 ppm, 8 h 1437 ppm):
Clinical signs: all static groups during exposure: blepharospasm, lacrimation, perinasal/perioral wetness, abdominal and/or mouth breathing hypoactivity, and an absence of startle reflex and motor activity.
Clinical signs observed on the day following exposure (6 and 8 h groups): lacrimation, narcosis and /or prostation, decreased respiratory rate, and an absence of toe and tail pinch, eye blink, and surface righting reflexes
Clinical signs observed during the subsequent postexposure period (6h and 8 h groups): periocular/perinasal encrustation, urogenital area wetness, hypoactivity, and decreased respiration rate
Clinical signs (4 h group postexposure): Narcosis was observed for the first 5 minutes following the end of exposure, followed by ataxia and periocular/perinasal wetness
Mortality: 4h group: 0/10, 6 h group 10/10, 8 h group 10/10, death occurred 1 to 4 days after exposure
LT50 value calculated: 5.66 (4.19 to 7.64)
Body weight gain: 4 h group: body weight gain observed 7 and 14 days after exposure
Necropsy of decedent (6 h and 8 h group: mottled red or bright pink discoloration of lungs, yellow staining of the urogential area, multiple ulcers on the tail, feet and paws, red or dark red discoloration of the thymus, liver, kidneys and brain, hemorrhages into the meninges or posterior cranial fossa (two animals 6 h group)
Applicant's summary and conclusion
- Executive summary:
Acute inhalation study
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
