Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature available

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1997

Materials and methods

Principles of method if other than guideline:
other: micronucleus assay in mice
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohex-3-ene-1-carbaldehyde
EC Number:
202-858-3
EC Name:
Cyclohex-3-ene-1-carbaldehyde
Cas Number:
100-50-5
Molecular formula:
C7H10O
IUPAC Name:
cyclohex-3-ene-1-carbaldehyde
Details on test material:
tetrahydrobenzaldehyde

Test animals

Species:
mouse
Strain:
ICR
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
once
Frequency of treatment:
once
Post exposure period:
24, 48 and 72 h after treatment
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 250, 500 or 1000 mg/kg bw
Basis:

No. of animals per sex per dose:
15 per dose and sex (at 1000 mg/kg bw an addtional group of 5 male and 5 female mice dosed with the test substance were designated as replacement animals in the event of mortality prior to the scheduled sacrifice time)
Control animals:
yes

Examinations

Tissues and cell types examined:
bone marrow cells were examined

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
yes
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Executive summary:

The test substance was negative in the in vivo micronucleus assay.