Registration Dossier
Registration Dossier
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EC number: 202-858-3 | CAS number: 100-50-5
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature available
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
- Principles of method if other than guideline:
- other: micronucleus assay in mice
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 202-858-3
- EC Name:
- Cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 100-50-5
- Molecular formula:
- C7H10O
- IUPAC Name:
- cyclohex-3-ene-1-carbaldehyde
- Details on test material:
- tetrahydrobenzaldehyde
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Post exposure period:
- 24, 48 and 72 h after treatment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 250, 500 or 1000 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 15 per dose and sex (at 1000 mg/kg bw an addtional group of 5 male and 5 female mice dosed with the test substance were designated as replacement animals in the event of mortality prior to the scheduled sacrifice time)
- Control animals:
- yes
Examinations
- Tissues and cell types examined:
- bone marrow cells were examined
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Executive summary:
The test substance was negative in the in vivo micronucleus assay.
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