Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

Currently viewing:

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Type of information:
experimental study
Adequacy of study:
supporting study

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2009
Report date:
2009
Reference Type:
secondary source
Title:
Unnamed
Year:
1999

Materials and methods

Principles of method if other than guideline:
Method data are not available as the report details are unpublished.

GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Warfarin
EC Number:
201-377-6
EC Name:
Warfarin
Cas Number:
81-81-2
Molecular formula:
C19H16O4
IUPAC Name:
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one

Test animals

Species:
mouse

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
in-vivo studies demonstrate the absence of a genotoxic potential of warfarin