Registration Dossier
Registration Dossier
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EC number: 811-357-4 | CAS number: 952-06-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: Report summary
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is based on study summary.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (Z)-N-(1,2-diphenylethylidene)hydroxylamine
- EC Number:
- 811-357-4
- Cas Number:
- 952-06-7
- Molecular formula:
- C14 H13 N O
- IUPAC Name:
- (Z)-N-(1,2-diphenylethylidene)hydroxylamine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): SC-65872
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium (TA97a, TA98, TA100, TA1535 and TA102).
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver homogenate metabolic activation system
- Test concentrations with justification for top dose:
- 10 to 5000 mcg/plate
- Vehicle / solvent:
- 100 mg/ml in dimethylsulfoxide (DMSO)
- Details on test system and experimental conditions:
- Testing was performed with and without a rat liver homogenate metabolic activation system over test article concentrations ranging from 10 to 5000 mcg/plate.
Results and discussion
Test results
- Species / strain:
- other: TA97a, TA98, TA100, TA1535 and TA102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- not mutagenic
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: strain/cell type: TA97a, TA98, TA100, TA1535 and TA102
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative Not mutagenic under the conditions of this test system.
SC-66276 is not mutagenic under the conditions of this test system. - Executive summary:
Test substance is not mutagenic under the conditions of the test system.
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