Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-721-0 | CAS number: 109-94-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from report for Health-based Reassessment of Administrative Occupational Exposure Limits. The Hague: Health Council of the Netherlands
Data source
Reference
- Reference Type:
- publication
- Title:
- Ethyl formate; Health-based Reassessment of Administrative Occupational Exposure Limits
- Author:
- Health Council of the Netherlands
- Year:
- 2 002
- Bibliographic source:
- Health Council of the Netherlands: Committee on Updating of Occupational Exposure Limits, 2002; 2000/15OSH/033
Materials and methods
- Objective of study:
- other: assessment of the health hazard of ethyl formate by the Committee on Updating of Occupational Exposure Limits, a committee of the Health Council of the Netherlands
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Guideline details not mentioned in the report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl formate
- EC Number:
- 203-721-0
- EC Name:
- Ethyl formate
- Cas Number:
- 109-94-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- ethyl formate
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- CAS No: 109-94-4
Chemical Name: Ethyl formate
Nature of chemical : Organic
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Inhalation, dermal & oral
- Vehicle:
- not specified
- Details on exposure:
- Details not available
- Duration and frequency of treatment / exposure:
- Details not available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Details not available
- No. of animals per sex per dose / concentration:
- Details not available
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Ethyl formate is readily absorbed into the blood via the alveoli of the respiratory system. It is also reported to be absorbed from the gastrointestinal tract and slightly through the skin
- Type:
- distribution
- Results:
- Distributed to the liver where it is metabolized.
- Type:
- metabolism
- Results:
- With moisture, ethyl formate readily hydrolyses into formic acid and ethanol. Formic acid is metabolised further by the tetrahydrofolate system to CO2. Ethanol is metabolised further to acetaldehyde, acetic acid,
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Enzymatic hydrolysis occurs. With moisture, ethyl formate readily hydrolyses into formic acid and ethanol. Formic acid is metabolised further by
the tetrahydrofolate system to CO2. Ethanol is metabolised further in the liver to acetaldehyde, acetic acid, and, finally, CO2, by alcohol dehydrogenase, aldehyde dehydrogenase, and the tricarbonic acid cycle, respectively.
Metabolites - formic acid, & ethanol. Ethanol is metabolised further in the liver to acetaldehyde, acetic acid, and, finally, CO2.
Any other information on results incl. tables
From the data available for the absorption, metabolism and excretion of the chemical ethyl formate and the maximum allowable concentration of 100 ppm (300 mg/m3), 8-hour TWA, it can be concluded that the chemical is likely to exhibit low bio-accumulation potential based on data reported in the reference.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
From the data available for the absorption, metabolism and excretion of the chemical ethyl formate and the maximum allowable concentration of 100 ppm (300 mg/m3), 8-hour TWA, it can be concluded that the chemical is likely to exhibit low bio-accumulation potential based on data reported in the reference. - Executive summary:
Data available in the present report on absorption, metabolism and excretion of the chemical ethyl formate and the metabolites formic acid, & ethanol & ethanol being metabolised further in the liver to acetaldehyde, acetic acid, and, finally, CO2 indicate thatoverloading of the buffer capacity of the body and subsequently, a metabolic acidosis is not expected.Also, from the reported elimination rates of ethanol it can be seen thataccumulation of metabolites will not occur. Thusthe chemical is likely to exhibit low bio-accumulation potential based on data reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
