Registration Dossier
Registration Dossier
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EC number: 203-643-7 | CAS number: 109-06-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary in a review article.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Initial submission: Toxicological investigation of: 0.4 mole fraction 2-methylpyridine with cover letter dated 08/17/92.
- Author:
- Birch, M.D.
- Year:
- 1 972
- Bibliographic source:
- Younger Laboratories Inc., report to Monsanto|Comp., April 19th, 1972, Monsanto Project No.Y-72-76, cited in US EPA 2009
- Reference Type:
- review article or handbook
- Title:
- SCREENING-LEVEL HAZARD CHARACTERIZATION Pyridine and Pyridine Derivatives Category
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 009
- Bibliographic source:
- http://www.epa.gov/hpvis/hazchar/Category%20Pyr%20and%20Pyr%20Derivs_Sept2009.pdf
Materials and methods
- Principles of method if other than guideline:
- New Zealand White rabbits (1/sex/dose) were administered the test substance dermally on to clipped hair at 79.4 (female), 200 (male), 316 (female), 501 (male), 1000 (female), or 2000 (male) mg/kg-bw under occluded conditions and observed for 14 days post exposure.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): 2-picoline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Doses:
- Females: 79.4, 316, 1000 mg/kg bw
Males: 200, 501 (male), 2000 (male) mg/kg bw - No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 200 - 316 mg/kg bw
- Mortality:
- All rabbits exposed to 316 mg/kg bw or above died within one day of exposure.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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