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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summary in a review article.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Initial submission: Toxicological investigation of: 0.4 mole fraction 2-methylpyridine with cover letter dated 08/17/92.
Author:
Birch, M.D.
Year:
1972
Bibliographic source:
Younger Laboratories Inc., report to Monsanto|Comp., April 19th, 1972, Monsanto Project No.Y-72-76, cited in US EPA 2009
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION Pyridine and Pyridine Derivatives Category
Author:
U.S. Environmental Protection Agency
Year:
2009
Bibliographic source:
http://www.epa.gov/hpvis/hazchar/Category%20Pyr%20and%20Pyr%20Derivs_Sept2009.pdf

Materials and methods

Principles of method if other than guideline:
New Zealand White rabbits (1/sex/dose) were administered the test substance dermally on to clipped hair at 79.4 (female), 200 (male), 316 (female), 501 (male), 1000 (female), or 2000 (male) mg/kg-bw under occluded conditions and observed for 14 days post exposure.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Details on test material:
- Name of test material (as cited in study report): 2-picoline

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Doses:
Females: 79.4, 316, 1000 mg/kg bw
Males: 200, 501 (male), 2000 (male) mg/kg bw
No. of animals per sex per dose:
1
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
200 - 316 mg/kg bw
Mortality:
All rabbits exposed to 316 mg/kg bw or above died within one day of exposure.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information