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EC number: 203-643-7 | CAS number: 109-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, non guideline study. Available as unpublished report. Restrictions in design and reporting but adequate for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
- Reference Type:
- review article or handbook
- Title:
- SCREENING-LEVEL HAZARD CHARACTERIZATION Pyridine and Pyridine Derivatives Category
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 009
- Bibliographic source:
- http://www.epa.gov/hpvis/hazchar/Category%20Pyr%20and%20Pyr%20Derivs_Sept2009.pdf
Materials and methods
- Principles of method if other than guideline:
- 0.5 mL of the test substance was applied to the skin of New Zealand White rabbits and covered with a patch for 4 hours. After exposure, the site was washed with water. Observations were made at removal of the test patch and at 24 and 48 hours.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): Alpha Picoline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: Stainless steel with elevated wire mesh flooring; 1 rabbit/cage
- Diet: Wayne 15% Rabbit Ration, ad libitum
- Water: Tap water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15.6 - 23.9
- Humidity (%): 40-45
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 48 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: approximately one square inch.
- Type of wrap if used: Surgical gauze patches measuring not less than 1" x 1" and two single layers thick were placed over the treated area and impervious material was wrapped snugly around the trunk of the animal to hold the patch in place.
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with water
- Time after start of exposure: 48 hours
SCORING SYSTEM:
Corrosion was considered to have resulted if the material in contact with the rabbit skin had caused destruction or irreversible alteration of the tissue. Tissue destruction was considered to have occurred if, at any of the readings, there was ulceration or necrosis. Tissue destruction was considered to have occurred if merely sloughing of the epidermis, erythema, edema or fissuring was evident. Observations of skin irritation, if any, encountered during testing of the material were noted.
Results and discussion
In vivo
Results
- Remarks on result:
- other: See "Irritant/corrosive response data"
- Irritant / corrosive response data:
- - 4 hours after exposure: Animal #1, 2, 3, 4 and 6 showed severe erythema, moderate edema and corrosion to the skin. Animal 5 showed slight erythema, moderate edema and no corrosion to the skin.
- 24 and 48 hours after exposure: Animal #1, 2 and 3 showed severe erythema, very slight edema and corrosion to the skin. Animal #4, 5 and 6 showed severe erythema, corrosion to the skin but no edema was observed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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