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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, non guideline study. Available as unpublished report. Restrictions in design and reporting but adequate for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION Pyridine and Pyridine Derivatives Category
Author:
U.S. Environmental Protection Agency
Year:
2009
Bibliographic source:
http://www.epa.gov/hpvis/hazchar/Category%20Pyr%20and%20Pyr%20Derivs_Sept2009.pdf

Materials and methods

Principles of method if other than guideline:
To assess the eye irritating potential of the test substance the undiluted compound was applied to the eye of a rabbit. The test was performed with and without washing of the eye following exposure.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Details on test material:
- Name of test material (as cited in study report): 2-picoline

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing: yes

Results and discussion

In vivo

Results
Remarks on result:
other: See "Irritant/corrosive response data"
Irritant / corrosive response data:
Washed and unwashed: Slight pain upon direct contact followed by severe conjunctival and corneal injury resulting in permanent impairment of vision and possibly total loss of sight. Corneal injury was apparent immediately after contact.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information