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Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, non guideline study. Available as unpublished report. Restrictions in design and reporting but adequate for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1984
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION Pyridine and Pyridine Derivatives Category
Author:
U.S. Environmental Protection Agency
Year:
2009
Bibliographic source:
http://www.epa.gov/hpvis/hazchar/Category%20Pyr%20and%20Pyr%20Derivs_Sept2009.pdf

Materials and methods

Principles of method if other than guideline:
In a six-month study, Sprague-Dawley rats (10/sex/dose) were exposed to 2-picoline vapor at 0, 5, 35, 100 ppm (0 and approximately 0.019, 0.133 or 0.38 mg/L/day) for 6 hours/day, 5 days/week.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Details on test material:
- Name of test material (as cited in study report): α-picoline

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Vehicle:
air
Duration of treatment / exposure:
6 months
Frequency of treatment:
6 hours/dday, 5days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
5, 35, 100 ppm (0.02, 0.13 or 0.38 mg/L)
Basis:
nominal conc.
Control animals:
yes, concurrent vehicle

Examinations

Observations and examinations performed and frequency:
Urinalysis, clinical chemistry, hematology, body weights, organ weights, sensor/motor fuction performance
Sacrifice and pathology:
Gross pathology and histopathology with special emphasis on the central nervous system

Results and discussion

Results of examinations

Details on results:
No effects were observed at all concentrations regarding body weights, urinalysis, hematology, clinical chemical parameters, organ weights, sensory/motor function performance, gross pathology, and histopathology.

Effect levels

Dose descriptor:
NOAEC
Effect level:
ca. 0.38 mg/L air
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: No effects observed up to the highest dose tested.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion