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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, non guideline study. Available as unpublished report. Restrictions in design and reporting but adequate for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1984
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION Pyridine and Pyridine Derivatives Category
Author:
U.S. Environmental Protection Agency
Year:
2009
Bibliographic source:
http://www.epa.gov/hpvis/hazchar/Category%20Pyr%20and%20Pyr%20Derivs_Sept2009.pdf

Materials and methods

Principles of method if other than guideline:
In a six-month study, Sprague-Dawley rats (10/sex/dose) were exposed to 2-picoline vapor at 0, 5, 35, 100 ppm (0 and approximately 0.019, 0.133 or 0.38 mg/L/day) for 6 hours/day, 5 days/week.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Details on test material:
- Name of test material (as cited in study report): α-picoline

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Vehicle:
air
Duration of treatment / exposure:
6 months
Frequency of treatment:
6 hours/dday, 5days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
5, 35, 100 ppm (0.02, 0.13 or 0.38 mg/L)
Basis:
nominal conc.
Control animals:
yes, concurrent vehicle

Examinations

Observations and examinations performed and frequency:
Urinalysis, clinical chemistry, hematology, body weights, organ weights, sensor/motor fuction performance
Sacrifice and pathology:
Gross pathology and histopathology with special emphasis on the central nervous system

Results and discussion

Results of examinations

Details on results:
No effects were observed at all concentrations regarding body weights, urinalysis, hematology, clinical chemical parameters, organ weights, sensory/motor function performance, gross pathology, and histopathology.

Effect levels

Dose descriptor:
NOAEC
Effect level:
ca. 0.38 mg/L air
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: No effects observed up to the highest dose tested.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion