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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary citation available, assessed by OECD SIDS

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acetic Anhydride
Author:
OECD SIDS
Year:
1997
Bibliographic source:
SIDS Initial Assessment Report for 6th SIAM (Paris, 9-11 June 1997)
Reference Type:
secondary source
Title:
Acetic acid and its derivatives: key properties and hazards.
Author:
Lodal PN
Year:
1992
Bibliographic source:
cited in: Eastman Chemical Company, Kingsport, Tennessee.

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetic anhydride
EC Number:
203-564-8
EC Name:
Acetic anhydride
Cas Number:
108-24-7
Molecular formula:
C4H6O3
IUPAC Name:
acetyl acetate
Details on test material:
- Name of test material (as cited in study report): Acetic Anhydride

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 000 mg/kg bw

Applicant's summary and conclusion