Registration Dossier
Registration Dossier
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EC number: 205-406-3 | CAS number: 140-26-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials – Phenethyl Isovalerate
- Author:
- Edited by: D. L. J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Monographs on Fragrance Raw Materials A Collection of Monographs Originally Appearing in Food and Cosmetics Toxicology 1979, Pages 635
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute dermal toxicity study was performed to determine the dermal toxic nature of the test compound Phenethyl isovalerate
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenethyl isovalerate
- EC Number:
- 205-406-3
- EC Name:
- Phenethyl isovalerate
- Cas Number:
- 140-26-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-phenylethyl 3-methylbutanoate
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):Phenethyl isovalerate- Molecular formula (if other than submission substance):C13H1802- Molecular weight (if other than submission substance): 206.28 g/mol- Substance type:Organic- Physical state:Liquid- Analytical purity: No data available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality wasn noted at 5000 mg/Kg bw
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The LD50 for phenethyl isovalerate was found to be greater than 5000mg/kg in rabbits.
- Executive summary:
In a acute dermal toxicity study, rabbits were treated with Phenethyl isovalerate in the concentration of 5000 mg/kg bw. No mortality was observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg bw when rabbit were treated with Phenethyl isovalerate dermally.
Based on the above value ,the test material does not classify as an acute dermal irritent.
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