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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials – Phenethyl Isovalerate
Author:
Edited by: D. L. J. Opdyke
Year:
1979
Bibliographic source:
Monographs on Fragrance Raw Materials A Collection of Monographs Originally Appearing in Food and Cosmetics Toxicology 1979, Pages 635

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Acute dermal toxicity study was performed to determine the dermal toxic nature of the test compound Phenethyl isovalerate
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl isovalerate
EC Number:
205-406-3
EC Name:
Phenethyl isovalerate
Cas Number:
140-26-1
Molecular formula:
C13H18O2
IUPAC Name:
phenethyl isovalerate
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report):Phenethyl isovalerate- Molecular formula (if other than submission substance):C13H1802- Molecular weight (if other than submission substance): 206.28 g/mol- Substance type:Organic- Physical state:Liquid- Analytical purity: No data available.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available.

Administration / exposure

Type of coverage:
open
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality wasn noted at 5000 mg/Kg bw
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
The LD50 for phenethyl isovalerate was found to be greater than 5000mg/kg in rabbits.
Executive summary:

In a acute dermal toxicity study, rabbits were treated with Phenethyl isovalerate in the concentration of 5000 mg/kg bw. No mortality was observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg bw when rabbit were treated with Phenethyl isovalerate dermally.

Based on the above value ,the test material does not classify as an acute dermal irritent.