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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

in vitro DNA damage and/or repair study
Type of genotoxicity: DNA damage and/or repair
Type of information:
experimental study
Adequacy of study:
weight of evidence
2 (reliable with restrictions)

Data source

Reference Type:
The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients
Adams, T.B. Cohen, S.M. Doull, J. Feron, V.J. Goodman, J.I. Marnett, L.J. Munro, I.C. Portoghese, P.S. Smith, R.L. Waddell, W.J. Wagner, B.M.
Bibliographic source:
Food and Chemical Toxicology, 8, 43, 2005, pp 1179-1206

Materials and methods

Principles of method if other than guideline:
To evaluate the genotoxicity of Isoamyl phenylacetate in Bacillus. Subtilis strain H17 (rec+) and M45 (rec-) by Rec assay.
GLP compliance:
not specified
Type of assay:
Bacillus subtilis recombination assay

Test material

Constituent 1
Reference substance name:
Isoamyl phenylacetate
Isoamyl phenylacetate
Constituent 2
Chemical structure
Reference substance name:
Isopentyl phenylacetate
EC Number:
EC Name:
Isopentyl phenylacetate
Cas Number:
Molecular formula:
3-methylbutyl phenylacetate
Test material form:
not specified
Details on test material:
Details on test material- Name of test material (as cited in study report): Isoamyl phenylacetate- Molecular formula (if other than submission substance): C13-H18-O2- Molecular weight (if other than submission substance): 206.283g/mol- Substance type: Organic - Physical state: OrganicPurity- Impurities (identity and concentrations): No data available.


Species / strain
Species / strain / cell type:
bacteria, other: Species: Bacillus. Subtilis strain : H17 (rec+) and M45 (rec-)
Test concentrations with justification for top dose:
20 μg/disk
Vehicle / solvent:
No data available.
Untreated negative controls:
not specified
Negative solvent / vehicle controls:
not specified
True negative controls:
not specified
Positive controls:
not specified
Evaluation criteria:
No data available.
No data available.

Results and discussion

Test results
Species / strain:
bacteria, other: Species: Bacillus. Subtilis strain : H17 (rec+) and M45 (rec-)
Metabolic activation:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Migrated from field 'Test system'.

Applicant's summary and conclusion

Interpretation of results (migrated information):negativeThe result was found to be negative for Isoamyl phenylacetate in Bacillus. Subtilis strain H17 (rec+) and M45 (rec-) by Rec assay.
Executive summary:

Genetox study for Isoamyl phenylacetate in Bacillus. Subtilis strainH17(rec+) and M45 (rec-) by Rec assay was conducted at the concentration of 20 μg/disk. At this concentration the result of Rec assay in Bacillus. Subtilis strainH17(rec+) and M45 (rec-) was found to be negative.