2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone

Endpoint summary

Key value for chemical safety assessment

Effects on fertility

Link to relevant study records

Reference

Endpoint:

screening for reproductive / developmental toxicity

Remarks:

based on test type (migrated information)

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is of Klimish 2 and from QSAR toolbox version 3.3

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

equivalent or similar to guideline

Guideline:

other: as below

Principles of method if other than guideline:

The prediction is done using the QSAR toolbox version 3.3 with log Kow as the preimary discriptor

GLP compliance:

not specified

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

no data available

Route of administration:

oral: gavage

Type of inhalation exposure (if applicable):

other: not applicable

Vehicle:

not specified

Details on mating procedure:

No data available

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

male: 50-52 d, female: 40-48 d (from 14 days before mating to the day 3 of lactation)

Frequency of treatment:

daily

Details on study schedule:

No data available

Remarks:

Doses / Concentrations:not reportedBasis:no data

No. of animals per sex per dose:

12/per dose group/sex

Control animals:

yes

Dose descriptor:

NOAEL

Effect level:

193 mg/kg bw/day (actual dose received)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other: no adverse effects

Remarks on result:

not determinable

Reproductive effects observed:

not specified

The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

(((("a" or "b" or "c" or "d" or "e" )  and ("f" and ( not "g") )  )  and "h" )  and ("i" and "j" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Hydrazines and Related Compounds by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Aryl AND Fused carbocyclic aromatic AND Naphtalene AND Phenol by Organic Functional groups

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Fused carbocyclic aromatic AND Overlapping groups AND Phenol by Organic Functional groups (nested)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Alcohol, olefinic attach [-OH] AND Aromatic Carbon [C] AND Hydrazine [>N-N<] AND Hydroxy, aromatic attach [-OH] AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach [-O-] by Organic functional groups (US EPA)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Aromatic compound AND Hydroxy compound AND Phenol by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OASIS v.1.3

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as Non-covalent interaction OR Non-covalent interaction >> DNA intercalation OR Non-covalent interaction >> DNA intercalation >> DNA Intercalators with Carboxamide Side Chain OR Non-covalent interaction >> DNA intercalation >> Fused-Ring Primary Aromatic Amines OR Radical OR Radical >> Radical mechanism via ROS formation (indirect) OR Radical >> Radical mechanism via ROS formation (indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >> Radical mechanism via ROS formation (indirect) >> Hydrazine Derivatives OR SN1 OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >> Fused-Ring Primary Aromatic Amines OR SN2 OR SN2 >> DNA alkylation OR SN2 >> DNA alkylation >> Alkylphosphates, Alkylthiophosphates and Alkylphosphonates by DNA binding by OASIS v.1.3

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Not bioavailable by Lipinski Rule Oasis ONLY

Domain logical expression index: "i"

Parametric boundary:The target chemical should have a value of log Kow which is >= 5.92

Domain logical expression index: "j"

Parametric boundary:The target chemical should have a value of log Kow which is <= 10

Conclusions:

The no observed adverse effect level (NOAEL) for 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone in a reproductive toxicity screening study in Crj: CD(SD) rats was estimated to be 193 mg/kg bw/day (actual dose received).

Executive summary:

The reproductive toxicity of 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone is estimated using QSAR toolbox 3.3.

The no observed adverse effect level (NOAEL) for 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone in a reproductive toxicity screening study in Crj: CD(SD) rats was estimated to be 193 mg/kg bw/day (actual dose received).

Effect on fertility: via oral route

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

NOAEL

193 mg/kg bw/day

Study duration:

subchronic

Species:

rat

Quality of whole database:

Data is of K2 level estimated using OECD QSAR toolbox 3.3

Effect on fertility: via inhalation route

Endpoint conclusion:

no study available

Effect on fertility: via dermal route

Endpoint conclusion:

no study available

Additional information

Toxicity to reproduction:

Based on the prediction done by using QSAR toolbox version 3.3 (2016), reproductive toxicity was evaluated in Crj: CD (SD) male and female rats by using 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazine orally by oral gavage. NOAEL was estimated to be 193 mg/kg bw/day (actual dose received) when Crj: CD (SD) male and female rats were treated with 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazine orally by oral gavage.

Thus, based on the above prediction done for 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazine (CAS no 2387-03-3) as per the CLP regulation is likely to be non hazardous to reproduction.

Short description of key information:
NOAEL was estimated to be 193 mg/kg bw/day (actual dose received) when Crj: CD (SD) male and female rats were treated with 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazine orally by oral gavage.

Justification for selection of Effect on fertility via oral route:
NOAEL was estimated to be 193 mg/kg bw/day (actual dose received) when Crj: CD (SD) male and female rats were treated with 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazine orally by oral gavage.

Justification for classification or non-classification

The chemical 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone was not found to be toxic in a reproductive toxicity study by the oral route.

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