Registration Dossier
Registration Dossier
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EC number: 201-398-0 | CAS number: 82-16-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Two rabbits were applied 500 µl of the test substance (Macrolexviolett 3R) at the inner side of one of the ears. The test material was fixed by an adhesive bandage for 24 hours. After 1 and 24 hours and 2, 3, 5, 6 and 7 days the skin areas were scored for erythema and edema according to Draize.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,8-bis[(4-methylphenyl)amino]anthraquinone
- EC Number:
- 201-398-0
- EC Name:
- 1,8-bis[(4-methylphenyl)amino]anthraquinone
- Cas Number:
- 82-16-6
- Molecular formula:
- C28H22N2O2
- IUPAC Name:
- 1,8-bis[(4-methylphenyl)amino]-9,10-dihydroanthracene-9,10-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not required
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 2 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point (up to 7 days)
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point (up to 7 days)
- Irritant / corrosive response data:
- Erythema and edema scores were = 0 at any time point.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Erythema and edema scores were = 0 at any time point.
- Executive summary:
Two rabbits were applied 500 µl of the test substance (Macrolexviolett 3R) at the inner side of one of the ears. The test material was fixed by an adhesive bandage for 24 hours. After 1 and 24 hours and 2, 3, 5, 6 and 7 days the skin areas were scored for erythema and edema according to Draize. Erythema and edema scores were = 0 at any time point. Macrolex Violet 3R was not irritating in this test.
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