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Registration Dossier
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EC number: 204-254-5 | CAS number: 118-47-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from Chemidplus report
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Chemidplus report for CAS 118-47-8
- Author:
- U.S.national library of medicine
- Year:
- 2 016
- Bibliographic source:
- ChemIDplus,A TOXNET DATABASE, Last updated: 21 June 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The data is from chemid plus
- Principles of method if other than guideline:
- Acute oral toxicity of chemical Pyrazolone T was determined.
- GLP compliance:
- not specified
- Test type:
- other: not reported
Test material
- Reference substance name:
- 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
- EC Number:
- 204-254-5
- EC Name:
- 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
- Cas Number:
- 118-47-8
- Molecular formula:
- C10H8N2O6S
- IUPAC Name:
- 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
- Reference substance name:
- Pyrazolone T
- IUPAC Name:
- Pyrazolone T
- Details on test material:
- - Name of test material: 5-Oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
- Molecular formula: C10H8N2O6S
- Molecular weight: 284.2472 g/mol
- Smiles notation: c1cc(ccc1N2C(=O)CC(=N2)C(=O)O)S(=O)(=O)O
- InChl: 1S/C10H8N2O6S/c13-9-5-8(10(14)15)11-12(9)6-1-3-7(
4-2-6)19(16,17)18/h1-4H,5H2,(H,14,15)(H,16,17,18)
- Substance type: Organic
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 22 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Lethality of test chemical
- Mortality:
- No data available
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.
- Executive summary:
Acute oral toxicity test was conducted on rat to evaluate the lethargic concentration of chemical Pyrazolone T.
The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.
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