Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol

Endpoint summary

Additional information

There are no data available investigating the aquatic toxicity of 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3, UVCB). In order to fulfil the standard information requirements, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted.

In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).

Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity, the substances 3,5,5-trimethylhexanoic acid hexaester with dipentaerythritol (CAS 84418-63-3, mono) and dipentaerythritol ester with fatty acids, C5 and C9iso (CAS 647028-25-9) as well as Fatty acids, C5 -9, hexaesters with dipentaerythritol (CAS 67762 -52 -1) are used as source substances.

The above mentioned substances are considered to be similar on the basis of the structural similar properties and/or activities. The available endpoint information on the source substances is used to predict the same endpoints for 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3, UVCB). The target and source substances are all esters of dipentaerythritol (DiPE), with four to six carboxylic fatty acid substituents. The fatty acid moieties comprise a chain length of C5 to C9, split in linear fatty acids and branched fatty acids (i.e. C9 branched).

The ester group is the common functional group in all members of the analogue approach and no other functional groups are present in the molecules. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).

All available experimental data on the source substances performed according to internationally accepted guidelines indicate no evidence of acute and chronic toxicity to aquatic organisms. Data for all three trophic levels are available. No toxicity was observed up to the limit of water solubility in all available experimental studies.

The degradation process in commercial sewage treatment plants is not suspected to be inhibited by the target substance. Available studies for both source substances performed with activated sludge from sewage treatment plants do not indicate a risk since respiration of activated sludge microorganisms was not inhibited.

Based on the result from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3, UVCB) exhibits no toxic effects on freshwater organisms up to the limit of the water solubility. As it can be seen in the data matrix of the analogue justification in IUCLID Section 13, all reliable data from the target and the source substance support the read-across by showing a consistent pattern of results.