Registration Dossier
Registration Dossier
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EC number: 205-503-0 | CAS number: 141-82-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- Justification for type of information:
- Malonic acid is a crystalline substance with particle size > 250 µm, and as such, is unlikely to be inhaled significantly into the respiratory tract. Malonic acid is also used in solution, however the known uses do not involve the generation of significant amounts of aerosols. Malonic acid is a metabolite of fatty acid oxidation and is naturally present in living organisms. It is of low acute oral toxicity, and any adverse effects from inhalation would be expected to be related to irritation effects from the relatively low pH. On this basis, further animal testing is considered to be unjustified.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
