Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-392-0 | CAS number: 84864-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Type of study:
- Draize test
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- female
- Route:
- intradermal and epicutaneous
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100 %
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100 %
- No. of animals per dose:
- 10
- Details on study design:
- (Traditional tests):
A. INDUCTION EXPOSURE
Induction was performed by intradermal injection and topical application of 100 % acetone according to the protocol of Magnusson and Kligman (no further details available)
B. CHALLENGE EXPOSURE
Challenge was performed 21 days after the initial intradermal injection by topical open application of 0.1 ml 100 % acetone to the shaved area of the flank
C. EVALUATION
48 hrs after the challenge application skin reactions were avaluated according to a modified scale for scoring:
erythema formation: grades from 0 to 4
edema formation: grades from 0 to 3
possible total maximum: 7
sensitization rate: number of animals with positve reaction/number of tested animals
mean response: [sum from all animals of (erythema score + edema score)] : numer of tested animals - Positive control substance(s):
- yes
- Remarks:
- 2-mercaptobenzothiazole
- Positive control results:
- Positve responses were found with 2-mercaptobenzothiazole with a sensitization rate of 5/5 and mean responses uo to 5.0 (depending on induction and challlenge concentrations)
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- Not sensitizing
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: Not sensitizing.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Non sensitizer Criteria used for interpretation of results: EU
- Conclusions:
- The test chemical sodium 2-(2 3-dihydro-1 3-dioxo-1H-inden-2-yl)quinoline-6-sulphonate is not a skin sensitizer.
- Executive summary:
Skin sensitization was estimated using SSS QSAR prediction model, 2016 using Guines pigs. The test chemical sodium 2-(2 3-dihydro-1 3-dioxo-1H-inden-2-yl)quinoline-6-sulphonate is not a skin sensitizer.
As per CLP classification, the test material is not likely to classify as a skin sensitizer.
Reference
The prediction was based on dataset comprised from the following descriptors: "S M W N"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a" or "b" or "c" or "d" or "e" ) and ("f" and ( not "g") ) ) and ("h" and ( not "i") ) ) and ("j" and ( not "k") ) ) and ("l" and ( not "m") ) ) and ("n" and ( not "o") ) ) and ("p" and "q" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Neutral Organics by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Aryl OR Diketone OR Fused carbocyclic aromatic OR Fused heterocyclic aromatic OR Indandione OR Pyridine OR Quinoline/ Isoquinoline OR Sulfonic acid by Organic Functional groups ONLY
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Aryl OR Fused carbocyclic aromatic OR Indandione OR Overlapping groups OR Quinoline/ Isoquinoline OR Sulfonic acid by Organic Functional groups (nested) ONLY
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] OR Aromatic Carbon [C] OR Aromatic Nitrogen OR Carbonyl, aliphatic attach [-C(=O)-] OR Carbonyl, olefinic attach [-C(=O)-] OR Carbonyl, one aromatic attach [-C(=O)-] OR Hydroxy, sulfur attach [-OH] OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or =C<] OR Suflur {v+4} or {v+6} OR Sulfinic acid [-S(=O)OH] OR Sulfonate, aromatic attach [-SO2-O] OR Tertiary Carbon by Organic functional groups (US EPA) ONLY
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Aromatic compound OR Carbonyl compound OR Ketone OR Sulfonic acid OR Sulfonic acid derivative by Organic functional groups, Norbert Haider (checkmol) ONLY
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as No alert found by DNA binding by OECD
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes OR SN1 OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium Ion formation >> Secondary aromatic amine by DNA binding by OECD
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules (GSH) by Protein binding potency
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as Highly reactive (GSH) OR Highly reactive (GSH) >> 2-Alken-1-als (MA) OR Highly reactive (GSH) >> Cinnamaldehydes (MA) OR Moderately reactive (GSH) OR Moderately reactive (GSH) >> Substituted 2-Alken-1-als (MA) by Protein binding potency
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Alkali Earth AND Non-Metals by Groups of elements
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as Halogens by Groups of elements
Domain logical expression index: "l"
Referential boundary: The target chemical should be classified as No alert found by Protein binding alerts for Chromosomal aberration by OASIS v1.1
Domain logical expression index: "m"
Referential boundary: The target chemical should be classified as AN2 OR AN2 >> Nucleophilic addition to pyridonimine tautomer of aminopyridoindoles or aminopyridoimidazoles OR AN2 >> Nucleophilic addition to pyridonimine tautomer of aminopyridoindoles or aminopyridoimidazoles >> Heterocyclic Aromatic Amines OR Radical mechanism OR Radical mechanism >> ROS generation and direct attack of hydroxyl radical to the C8 position of nucleoside base OR Radical mechanism >> ROS generation and direct attack of hydroxyl radical to the C8 position of nucleoside base >> Heterocyclic Aromatic Amines OR SE reaction (CYP450-activated heterocyclic amines) OR SE reaction (CYP450-activated heterocyclic amines) >> Direct attack of arylnitrenium cation to the C8 position of nucleoside base OR SE reaction (CYP450-activated heterocyclic amines) >> Direct attack of arylnitrenium cation to the C8 position of nucleoside base >> Heterocyclic Aromatic Amines OR SR reaction (peroxidase-activated heterocyclic amines) OR SR reaction (peroxidase-activated heterocyclic amines) >> Direct attack of arylnitrenium radical to the C8 position of nucleoside base OR SR reaction (peroxidase-activated heterocyclic amines) >> Direct attack of arylnitrenium radical to the C8 position of nucleoside base >> Heterocyclic Aromatic Amines by Protein binding alerts for Chromosomal aberration by OASIS v1.1
Domain logical expression index: "n"
Referential boundary: The target chemical should be classified as Not known precedent reproductive and developmental toxic potential by DART scheme v.1.0
Domain logical expression index: "o"
Referential boundary: The target chemical should be classified as C1 to C4 non-branched alkyl alcohols- sub category (25a) OR Known precedent reproductive and developmental toxic potential OR Multi-halogenated alkyl ethers (23b) by DART scheme v.1.0
Domain logical expression index: "p"
Parametric boundary:The target chemical should have a value of log Kow which is >= -2.27
Domain logical expression index: "q"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.89
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Prediction model based estimation and data from read across chemical are used to predict the skin sensitization potential of the test chemical CAS no 84864 -68 -6. The summary is as follows:
Skin sensitization was estimated using SSS QSAR prediction model, 2016 using Guines pigs. The test chemical sodium 2-(2 3-dihydro-1 3-dioxo-1H-inden-2-yl)quinoline-6-sulphonate (CAS no 84864 -68 -6) is not a skin sensitizer.
Maximization test was performed (Kita et al, 1984) to study the sensitizing potential of the test chemical D & C Yellow no.10 (CAS no 8004 -92 -0). 5% of the test chemical was used in the induction phase. Five 48 hrs exposure were given on the upper right arm using Duhring chambers (120 mm in diameter) on sites pretreated with sodium lauryl sulfate. None of the 15 subjects exposed to induction doses of 5% test chemical in water became sensitized. The test chemicalD & C yellow no 10 is thus not sensitizing to the skin of humans.
Repeat insult patch test was conducted (Weaver, 1983) to evaluate the sensitizing potential of the test compound D & C yellow no 10 (CAS no 8004 -92 -0) with groups of volunteers in the St. Petersburg, Florida area. The materials for these tests were varying concentrations of D & C Yellow No. 10 in an aqueous soap vehicle. The patches employed were occlusive Parke Davis clinical Readi-Band® patches (20 mm square non-woven cotton pads on 37 mm square Blenderm® Surgical Tape). 0.3 ml of the test liquids was measured onto each pad to achieve saturation. Patches were applied to the same test sites on the upper arm each Monday, Wednesday and Friday for 24 h exposures for 3 weeks during the induction phase of the tests. Following a 2-week rest period, challenge patches of the same test material were applied to the initial test sites as well as to naive sites on the contralateral arms for 24 h. Scoring of induction patches was performed immediately prior to application of succeeding patches and 48 h following removal of the 9th patch during induction.Scoring of challenge patches was performed 48 h and 96 h following patch application. Greater skin response at challenge compared with the response at the original exposure was considered suggestive of cutaneous sensitization. Positive ( +, + +, + + +) reactions occurring early in the induction phase of the tests were considered suggestive of preexistant hypersensitivity. No signs of pre-existant or induced delayed contact hypersensitivity were produced by any of these concentrations. In addition, a non-certified Acid Yellow 3 produced no signs of hypersensitivity in a repeat insult patch test of0.1% of the dye in the 0.5% w/v aqueous soap vehicle.
Modified Buehler Method was conducted (lamson, 1982) to evaluate the sensitizing potential of the test compound D & C yellow no 10 (CAS no 8004 -92 -0). Adult female albino guinea pigs (Hartley Strain), initially weighing 300-500 g, were housed 5 per cage. The induction phase was accomplished with a 24-h occluded patch in the nuchal area once weekly for 3 consecutive weeks. Test and vehicle control groups were run concurrently. Following a 2-week rest period, the guinea pigs were challenged with a 24 h occluded patch containing the appropriate dye. Each test group was initially challenged with the dye used during the induction phase. Challenge concentrations for each dye were 1.0, 3.0 and 10.0%. Animals induced with D & C Yellow No. 11 were challenged with commercial products containing the D & C Yellow No. 11 or D & C Yellow No. 10. After the patches were removed, the guinea pigs were rested for 24 h, depilated with a chemical depilatory (Neet), and evaluated for erythema and edema. Guinea pigs treated with D & C Yellow No. 10 and challenged with 1, 3 and 10% did not exhibit sensitization responses. The test material D & C yellow no 10 is not sensitizing to the skin of guinea pigs in the modified Buehler test performed.
As per CLP classification, the test material is not likely to classify as a skin sensitizer.
Migrated from Short description of key information:
Skin sensitization was estimated using SSS QSAR prediction model, 2016 using Guines pigs. The test chemical sodium 2-(2 3-dihydro-1 3-dioxo-1H-inden-2-yl)quinoline-6-sulphonate is not a skin sensitizer.
Justification for selection of skin sensitisation endpoint:
The test chemical sodium 2-(2 3-dihydro-1 3-dioxo-1H-inden-2-yl)quinoline-6-sulphonate is not a skin sensitizer.
Justification for classification or non-classification
Skin sensitization:
As per CLP classification, the test material sodium 2-(2 3-dihydro-1 3-dioxo-1H-inden-2-yl)quinoline-6-sulphonate is not likely to classify as a skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.