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EC number: 201-346-7 | CAS number: 81-39-0
Endpoint summary
Administrative data
Description of key information
Biodegradation in water: screening tests
Biodegradability of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS no. 81 -39 -0) was estimated by uisng OECD QSAR tool box v3.3 by considering nine closest read across chemicals with log Kow as primary descriptor. The test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione undergoes 2.677 % biodegradation by considering BOD as parameter and microorganisms as inoculum in 28 days. On the basis of percent degradability value it can be concluded that this test chemical is not readily biodegradable.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS no.81 -39 -0) . If released in to the environment, 10.9 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione in sediment is estimated to be 541.66 days (8100 hrs). Based on this half life value it concluded that this test chemical in not persistent in sediment as well.
Biodegradation in soil:
The half-life period of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione(CAS no.81 -39 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.4 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione in soil is estimated to be 120 days (2800 hrs). Based on this half-life value of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione , it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
Additional information
Biodegradation in water: screening tests
Predicted data studies for target chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS no. 81 -39 -0) and experimental studies for its read across chemicals have been conducted and their results are summarized below to determined biodegradability of test chemical by applying weight of evidence approach.
In first weight of evidence study the biodegradability of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS no. 81 -39 -0) was estimated by uisng OECD QSAR tool box v3.3 by considering nine closest read across chemicals with log Kow as primary descriptor. The test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione undergoes 2.677 % biodegradation by considering BOD as parameter and microorganisms as inoculum in 28 days. On the basis of percent degradability value it can be concluded that this test chemical is not readily biodegradable.
Next weight of evidence study was done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione(CAS no.81 -39 -0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione is expected to be readily biodegradable.
The supporting weight of evidence study for done for structurally similar read across chemical disodium 2,2'-[(9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)diimino]bis(5-methylbenzenesulfonate) (CAS no.4403-90-1) from authoritative database (HSDB, 2017) in this study the read across chemical showed 0.0% biodegradation by considering theoretical BOD as parameter in 5 days, in aerobic condition and by taking sewage sludge as inoculums. So it is concluded that read across chemical disodium 2,2'-[(9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)diimino]bis(5-methylbenzenesulfonate) is not readily biodegradable.
Next supporting weight of evidence study was also done from same source as mentioned in above supporting Study (HSDB, 2017) in this study the biodegradation of read across chemical 2-cyclohexylsulfanylisoindole-1,3-dione (CAS no.17796-82-6) was determined to be 3.4 % by theoretical CO2 evolution parameter for 32 days by shake flask test. On the basis of percent degradability value it is concluded that read across chemical 2-cyclohexylsulfanylisoindole-1,3-dione is not readily biodegradable.
On the basis of above results for target chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS no. 81 -39 -0) from ( EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across substances (from authoritative database) the target chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione can be expected to be not readily biodegradable.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS no.81 -39 -0) . If released in to the environment, 10.9 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione in sediment is estimated to be 541.66 days (8100 hrs). Based on this half life value it concluded that this test chemical in not persistent in sediment as well.
Biodegradation in soil:
The half-life period of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione(CAS no.81 -39 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.4 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione in soil is estimated to be 120 days (2800 hrs). Based on this half-life value of test chemical 3-methyl-6-[(4-methylphenyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione , it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
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