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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The median Effective concentration (EC50) value for 6-chlorohexan-2-one on Daphnia magna in a 48 hour study was estimated to be 980 mg/L on the basis of intoxication effects.

Thus the chemical is not expected to exhibit aquatic toxicity as per the CLP criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
980 mg/L

Additional information

Various predicted studies for the 6-Chlorohexan-2-one were reviewed to summarize the following information: 

48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the 6-Chlorohexan-2-one (CAS no 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the 6-Chlorohexan-2-one was estimated to be980 mg/Lon the basis of mobility.

 

48 hrs aquatic toxicity study (Danish QSAR, 2016) was conducted to assess toxic effects of the 6-Chlorohexan-2-one (CAS no 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the 6-Chlorohexan-2-one was estimated to be 175.914 mg/l. 

  

48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1,2016) was conducted to assess toxic effects of the 6-Chlorohexan-2-one (CAS no 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 6-Chlorohexan-2-one was estimated to be 171.188 mg/Lon the basis of mobility.

On the basis of results of various predictions, the6-Chlorohexan-2-onecan be considered as not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and can be classified as non- hazardous as per the criteria of CLP regulation