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EC number: 233-546-5 | CAS number: 10226-30-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72 hrs aquatic toxicity study was predicted (SSS QSAR Prediction model, 2016) to assess toxic effects of the test compound6-Chlorohexan-2-one(CAS No. 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Pseudokirchnerella subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound6-Chlorohexan-2-one(CAS No. 10226-30-9) was estimated to be 243.371 mg/l on the basis of growth rate. . Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 243.37 mg/L
Additional information
Various predicted data for the target chemical 6-Chlorohexan-2-one (CAS No. 10226-30-9) were reviewed to summarize the following information:
72 hrs aquatic toxicity study was predicted (SSS QSAR Prediction model, 2016) to assess toxic effects of the test compound6-Chlorohexan-2-one(CAS No. 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Pseudokirchnerella subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound6-Chlorohexan-2-one(CAS No. 10226-30-9) was estimated to be 243.371 mg/l on the basis of growth rate. . Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10 (EPI suite, 2016), the 96 hours EC50 was estimated to be 105.05 mg/l on green algae for substance6-Chlorohexan-2-one(CAS No. 10226-30-9) with growth inhibition effects. Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
Estimated 72 hrs EC50 value (Danish QSAR database, 2016) of test substance 6-Chlorohexan-2-one on Pseudokirchneriella subcapitata was determined by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database. Based on inhibition in growth rate of test organism Pseudokirchneriella subcapitata, the estimated 72 hrs EC50 value was found to be 30.991mg/l. Thus, based on this value, it can be concluded that the substance can be considered as toxic to aquatic organisms and thus can be classified as aquatic chronic category 3.Since the test substance is readily biodegradable in nature and the partition coefficient (log Kow) of the test chemical is not ≥ 4 (i.e, reported as 1.49), test chemical can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
Based on the overall reported results of various study for target substance, it can be concluded that the substance can be classified as not hazardous as per the CLP criteria.
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