Registration Dossier
Registration Dossier
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EC number: 233-546-5 | CAS number: 10226-30-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fragrance raw materials monographs RIFM
- Author:
- Moreno, O. M.
- Year:
- 1 988
- Bibliographic source:
- Food and Chemical Toxicology Volume 26, Issue 4, 1988, Pages 393
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Details of guidelines not mentioned
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Nonan-2-one
- EC Number:
- 212-480-0
- EC Name:
- Nonan-2-one
- Cas Number:
- 821-55-6
- IUPAC Name:
- nonan-2-one
- Reference substance name:
- 2-nonanone
- IUPAC Name:
- 2-nonanone
- Details on test material:
- - Name of test material (as cited in study report): 2-nonanone
- Molecular formula (if other than submission substance): C9H18O
- Molecular weight (if other than submission substance): 142.24g/mol
- Substance type: Organic
- Physical state: colorless to pale yellow clear oily liquid
Purity No data available
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 24 hour
- Doses:
- >5000 mg/kg
- No. of animals per sex per dose:
- 7
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed in all seven animals.
- Mortality:
- No mortality was observed in all seven animals.
- Clinical signs:
- Irritation and scaly skin was observed.
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose (LD50) was found to be >5000mg/kg for 2-nonanone in rabbit.
- Executive summary:
In acute dermal study for2-nonanone in rabbit was found to be >5000mg/kg .As though mortality was not observed in all seven rabbits at concentration of 5000 mg/kg but Irritation and scaly skin was observed at necropsy.
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