3,5,5-trimethylcyclohex-3-en-1-one

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

open literature. Data were taken from the structural analogue beta-Isophoron, CAS 78-59-1. The structural analogue differs in the location of the carbon double bound within the ring structure of the molecule, whereas the rest of the molecule is identical to CAS 471-01-2.

Data source

Reference

Reference Type:

publication

Title:

Toxicity of acenaphthene and isophorone to early life stages of fathead minnows

Author:

Cairns MA, Nebeker AV

Year:

1982

Bibliographic source:

Arch. Environ. Contam. Toxicol. 11, 703-707

Materials and methods

Principles of method if other than guideline:

Stephan, C.E. (1975): Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. Ecol. Res. Ser. EPA-660/3-75-009 Gorvallis, OR: US. Environ. Prot. Agency

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

3,5,5-trimethylcyclohex-2-enone

EC Number:

201-126-0

EC Name:

3,5,5-trimethylcyclohex-2-enone

Cas Number:

78-59-1

IUPAC Name:

3,5,5-trimethylcyclohex-2-en-1-one

Sampling and analysis

Analytical monitoring:

yes

Details on sampling:

MONITORING OF TEST SUBSTANCE CONCENTRATION
- twice weekly, HPLC

Test organisms

Test organisms (species):

Pimephales promelas

Details on test organisms:

- Age: Initial age 3 weeks

Study design

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Test conditions

Test temperature:

24.5 ± 1 °C

pH:

7.4 (7.1-7.6)

Dissolved oxygen:

7.9 (6.2-8.4) mg/l

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

145 mg/L

Conc. based on:

test mat.

Basis for effect:

mortality (fish)