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EC number: 930-964-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 01.03.1979 to 29.05.1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method equivalent to OECD guideline 402. No GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Internal guideline, valid at the time of study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Monochloressigsäure
- Physical state: white crystalline flakes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Own breeding
- Strain: Hoe WISKf (SPF71)
- Weight at study initiation: 160 - 208 g (x = 183 g, s = ± 13 , 08 g, n = 48).
- Housing: Animals were housed individually in plastic cages; bottom: wood shavings.
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum.
- Water (e.g. ad libitum): Tap water, ad libitum.
The test was performed in female rats, because in preliminary tests, a higher sensitivity could be determined.
IN-LIFE DATES: From: 01.03.1979 To: 16.04.1979
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Application on depilated back skin (ca. 30 cm²).
- Type of wrap if used: After dosage, skin covered using an alumina foil 6x8 cm, fixed by an elastic plaster (Elastoplast, 8 cm width) around the body. - Duration of exposure:
- 24 hours
- Doses:
- 50; 100, 200, 400 mg/kg; concentrations used: 1, 1, 5, 5 % respectively.
200, 280, 400, 2000 mg/kg; concentration used: 40 %. - No. of animals per sex per dose:
- 6 female rats per group
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were weighed weekly.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Toxicity symptoms, the mortality rate and death time were recorded. - Statistics:
- LD50 calculation was based on probit analysis with a method according to Linder & Weber. The confidence limits were calculated according to Cavalli-Sforza; calculation program by Hoechst AG, department for Practical Mathematics.
To calculate the LD 50 were used only the results after administration of the 40% dilution.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 305 mg/kg bw
- 95% CL:
- 242 - 384
- Mortality:
- Animals died between 3.5 and 24 hours.
- Clinical signs:
- In dead animals during the study, the following symptoms were observed: piloerection, passivity, widened palpebral fissure , motoric unrest, belly lie, miosis, increased lachrymation, fitful breathing.
All surviving animals were free of symptoms 48 hours post application.
The behavior during the observation period was normal. - Body weight:
- The body weight gain during the observation period was normal.
- Gross pathology:
- Dead animals during the study: lungs dark red coloured, spotted; small intestines reddened and autolysis.
After the 2000 mg/kg dose: brownish skin colouration near the application area, muscle tissue beneath deeply white-grey coloured approx. 1 mm in depth.
Surviving animals: without macroscopic findings.
Any other information on results incl. tables
Table 07.02.03_01. Mortality rate.
Dosis (mg/kg) | concentration (%) | dead animals / animals used |
50 | 1 | 0/6 |
100 | 1 | 0/6 |
200 | 5 | 0/6 |
400 | 5 | 0/6 |
200 | 40 | 0/6 |
280 | 40 | 4/6 |
400 | 40 | 4/6 |
2000 | 40 | 6/6 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A LD50 of 305 (242 - 384) mg/kg bw was determined by Probit.
- Executive summary:
A study of the acute dermal toxicity was performed on female Wistar rats. Test method was equivalent to OECD guideline 402. Animals were exposed for 24 hours to test substance (50; 100, 200, 400 mg/kg; concentrations used: 1, 1, 5, 5 % respectively. 200, 280, 400, 2000 mg/kg; concentration used: 40 %). Six rats per dose were used. After an observation period of 14 days, a LD 50 of 305 (242 - 384) mg/kg bw was determined by Probit.
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