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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No data on test method. No GLP.

Data source

Reference
Reference Type:
publication
Title:
Materials for experimentally substantiation of maximally permissible concentration of monochloroacetic acid in the air of production area
Author:
Maksimov GG, Dubinina ON
Year:
1974
Bibliographic source:
Gig. Tr. Prof. Zabol. (1974), 9, 32-37

Materials and methods

Principles of method if other than guideline:
The sensitisation effect of monochloractic acid was studied on rabbits for 30 days.
No more data provided on the method.
GLP compliance:
no
Type of study:
open epicutaneous test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): МХУК
- Physical state: colorless hygroscopic crystals

In vivo test system

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, open
Vehicle:
no data
Concentration / amount:
Induction: 0.1, 1.5, 10 and 50% solution
Challenge: 5 % solution
Challengeopen allclose all
Route:
epicutaneous, open
Vehicle:
no data
Concentration / amount:
Induction: 0.1, 1.5, 10 and 50% solution
Challenge: 5 % solution
No. of animals per dose:
No data
Details on study design:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Concentrations: 1 drop of 0.1, 1.5, 10 and 50% solution
- Area of exposure: 6 cm2

B. CHALLENGE EXPOSURE
- No. of exposures: 30
- Exposure period: 30 days, daliy
- Evaluation (hr after challenge): 10 drops of 5 % solution
- Area of exposure: 6 cm2
Positive control substance(s):
not specified

Results and discussion

Any other information on results incl. tables

No animals were sensitized.

Applicant's summary and conclusion

Interpretation of results:
other: due to the limited reporting of this study is not considered reliable for the evaluation of the sensitizing potential of the substance.
Conclusions:
No animals were sensitized.
Executive summary:

The sensitisation effect of monochloractic acid was studied experimentally on rabbits for 30 days.

No animals were sensitized.