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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Description of key information

According the result of the key study (OECD method 429, GLP, Klimisch 1), the registered substance Jarocol Violet 43 was considered to be not a skin sensitizer.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

One key study was available to assess the potential sensitizing effect of the registered substance which was a Local Lymph Node Assay (LLNA) according to OECD 429 method.

In this key study, mice were separated in 7 groups consisting of 5 treated groups receiving Jarocol Violet 43, a negative control group receiving the vehicle (AOO) alone and a positive control group receiving alpha-hexylcinnamaldehyde (HCA). During induction period test substances were applied over the ears for three consecutive days. After 2 days of resting, the proliferation of lymphocytes in the lymph nodes draining the application sites was measured by incorporation of tritiated methyl thymidine (day 6). The irritant potential of the test item was assessed in parallel by measurement of ear thickness on days 1, 2, 3 and 6. No cutaneous reactions and no increases in ear thickness were observed in animals treated with the test substance. No lymphoproliferation was observed at any tested concentration (SI ranging from 0.9 for 0.6% to 1.6 for 15% active dye). There was no delayed hypersensibility contact. (Griffon 2004)

Justification for classification or non-classification

According the result of the key study (OECD method 429, GLP, Klimisch 1), the registered substance Jarocol Violet 43 was considered to be not a skin sensitizer.