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PBT assessment

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PBT assessment: overall result

Type of composition:
boundary composition of the substance
State / form:
Reference substance:
PBT status:
the substance is not PBT / vPvB

Classification of 2-Octanone (CAS no. 111-13-7) for effects in the environment:

Thetest chemical 2-Octanone(CAS no. 111-13-7) is used in the biocides, washing, air care, polishes, waxes perfumes fragrances and personal care products.The test chemicalherein critically and independently evaluated the environmental fate and ecotoxicity data.


The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for2-Octanone. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.

1. Persistence assessment


The tested substance doesn’t meet the P criterion within Annex XIII based on the assessment that here follows:


1.1.Overall degradability


Experimental study of the test chemical, 2-Octanone was investigated for the biodegradation nature. The results from the experiment indicates test substance to be inherent biodegradable, showing a biodegradation of 42.16% in 35 days.


1.2. Environmental fate and exposure risk



The test chemical 111-13-7, if released purposefully or accidentally into the environmental media. It is predicted that the test chemical would mostly accumulate in the soil up to 65.2% followed by water (32.2%) and sediment (0.117%).


Table 2:Summary of estimated half-life and Mackay Fugacity model (level III) in freshwater, sediment and soil by EPI suite version 4.1:



Predicted half-life

Mackay fugacity model level III

fresh- or estuarine water

15 days


fresh- or estuarine sediment

135 days



30 days



In conclusion, the chemical was estimated to be non-persistent in water,it doesn’t meet the criteria of the persistence as per ANNEX XIII.


2. Bioaccumulation assessment


The tested substance doesn’t meet the B criterion within Annex XIII based on the assessment that here follows:

I.                   The data from the section 4.7, of partition Coefficient n-octanol/water of test chemical is 1.9565. Based on the very low logKow values (below 4) it is expected that the test chemical will have very low potential to get bioaccumulate in the aquatic organisms. 

J.                  Various data of the test chemical in relation to bioaccumulation study reveals that the test chemical has very low potential to get accumulate in the visceral organs of the aquatic species. The BCF value of test compound ranges from 13 to 46.7, which is lower than the standard value 2000.

3.    Toxicity assessment


The tested substance doesn’t meet the T criterion within Annex XIII based on the assessment that here follows:


3.1. Mammals


The substance didn’t fulfil the criteria for the mammalian toxicity, neither CMR nor STOT RE as per ANNEX XIII of PBT classification.


3.2. Freshwater organisms

The investigation of test chemical was done to observe any adverse effects caused to the aquatic organisms. By careful examination of all the data of ecotox endpoints of the test chemical, the toxic values of the test chemical were greater than >32.2. Considering it toxic values is can be regarded as the slightly hazardous chemical to the aquatic environments and categorised into aquatic chronic 3. In view of median values, it can be hypothesized that the test chemical will not have NOEC values below 0.01mg/L. Thus, relying on the data obtained it can be concluded the test chemical may not cause any effect on long term exposure stating that chemical is safe and non-toxic.  


Overall conclusion about Persistence, Bioaccumulation and Toxicity (PBT).

Based on critical, independent and collective evaluation of information summarized herein, the tested compound didn’t meet the P-, B- and T criterion within Annex XIII. Hence, the tested compound has not been classified as a PBT compound within Annex XIII.