Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 943-553-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- The study was conducted between 30 May 1977 and 16 June 1977.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modified Federal Hazard Substances labelling Act Method
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP.
Test material
- Reference substance name:
- Reaction mass of 2,4-dimethyl-6-phenyl-3,6-dihydro-2H-pyran and 2-methyl-4-methylene-6-phenyltetrahydro-2H-pyran and 4,6-dimethyl-2-phenyl-3,6-dihydro-2H-pyran
- Molecular formula:
- C13H160
- IUPAC Name:
- Reaction mass of 2,4-dimethyl-6-phenyl-3,6-dihydro-2H-pyran and 2-methyl-4-methylene-6-phenyltetrahydro-2H-pyran and 4,6-dimethyl-2-phenyl-3,6-dihydro-2H-pyran
- Test material form:
- other: Liquid
- Details on test material:
- Name: Pelargene
Chemical name: 2,4-dimethyl-6-phenyldihydropyran
Appearance: Colourless liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- 22 days
- Number of animals or in vitro replicates:
- Three
- Details on study design:
- Test substances are applied to one eye each of three rabbits by gently pulling the lower lid away from the eyeball and placing 0.1 mL in the sac so formed. Standards for comparison are applied to further rabbits in the same manner.
Eyes are examined 24 hours after treatment and thereafter at daily intervals and graded for corneal, conjunctival and iridial damage. Eyes are examined before application of the materials and at daily intervals afterwards with a slit lamp and corneal swelling is measured.
Modification of standard method
Area of cornea and iris affected was assessed as well as intensity.
Results and discussion
In vivo
- Irritant / corrosive response data:
- The test substance, as supplied, caused no corneal, conjunctival or iridial lesions when assessed at 24 h. One rabbit showed signs of discomfort when treated.
Any other information on results incl. tables
Summary of results
Substance |
No. of rabbits |
Number of rabbits with stated ocular lesion |
||||||||||||||||
Discomfort |
Positive conjunctival reactions (1) |
No. with iritis |
No with pannus |
Corneal opacity grade (2) |
Duration (3) |
Maximum corneal swelling % (4) |
||||||||||||
0.5 |
1 |
2 |
3 |
4 |
Opacity≥1 Day 8 |
Opacity≥0.5 day 22 |
-10 % to +19 % |
+ 20 % to +39 % |
+40 % to +59 % |
+60 % to + 79 % |
+80 % to + 79 % |
+100 % |
||||||
Test substance |
3 |
1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
3 |
|
|
|
|
|
1) Positive conjunctival reactions – number of rabbits with conjunctival erythema or chemosis grades ≥2.
2) Corneal opacity - maximum grade obtained during period of observation.
3) Duration – number of animals with corneal opacity grades ≥1 on 8thday of observation or with any ocular lesions on the 22ndday of the test.
4) Corneal swelling - maximum swelling attained during period of observation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance, as supplied, is not an eye irritant. This material may cause pain if accidentally splashed into the eye.
- Executive summary:
The test substance was assessed for eye irritation using an in vivo method. The test substance, as supplied, caused no corneal, conjunctival or iridial lesions when assessed at 24 h. One rabbit showed signs of discomfort when treated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.