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Registration Dossier
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EC number: 209-795-0 | CAS number: 593-51-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data from peer reveiw publication
Data source
Reference
- Reference Type:
- publication
- Title:
- INHALATION TOXICOLOGY OF METHYLAMINE
- Author:
- A. Kinney, R. Valentine, H. C. Chen, R. M. Everett, and G. L. Kennedy,
- Year:
- 1 990
- Bibliographic source:
- Inhalation Toxicology, 2:29-39, 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate the acute toxicity of Methylamine hydrochloride in rats.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Methylammonium chloride
- EC Number:
- 209-795-0
- EC Name:
- Methylammonium chloride
- Cas Number:
- 593-51-1
- Molecular formula:
- CH5N.ClH
- IUPAC Name:
- methanamine
- Reference substance name:
- Methylamine hydrochloride
- IUPAC Name:
- Methylamine hydrochloride
- Details on test material:
- - Name of test material (as cited in study report): Methylamine hydrochloride
- Molecular formula (if other than submission substance): CH5N.Cl H
- Molecular weight (if other than submission substance): 67.5184 g/mol
- Substance type: Organic
- Physical state:
Purity No data available.
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methylamine hydrochloride (methanaminium chloride)
- Molecular formula (if other than submission substance): CH5N.Cl H
- Molecular weight (if other than submission substance): 67.5184 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available.
- Doses:
- 1600 to 3200 mg/kg
- No. of animals per sex per dose:
- No data available.
- Control animals:
- not specified
- Details on study design:
- No data available.
- Statistics:
- No data available.
Results and discussion
- Preliminary study:
- No data available.
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 600 - 3 200
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed.
- Clinical signs:
- other: No data available.
- Gross pathology:
- No data available.
- Other findings:
- No data available.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Conclusions:
- LD50 was considered to be 1600 mg/kg for Methylamine hydrochloride in rats by oral administration.
- Executive summary:
In a acute oral toxicity study, rats were treated with methanaminium chloride orally. The LD50 was observed at the dose level of 1600 mg/kg bw in the range of 1600 to 3200 mg/kg.
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