Registration Dossier
Registration Dossier
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EC number: 432-130-2 | CAS number: 119345-01-6
Endpoint summary
Administrative data
Description of key information
Additional information
Data is available for the endpoints biodegradation in water (screening tests), bioaccumulation and adsorption/desorption. The biodegradation studies have been obtained from ECHA through the inquiry process and are therefore considered as reliable with restrictions. The bioaccumulation and the adsorption potential have been estimated by calculation using a scientifically accepted calculation method and are therefore also considered as reliable with restrictions. Hydrolysis has been omitted due to the low water solubility of the substance. An attempt to conduct the study was made, but it was not possible to conduct the test in water or the associated buffers to assess preliminary hydrolysis due to the insufficient solubility of the substance.
Biodegradation
The test substance was neither readily biodegradable (0 % degradation after 28 d) nor inherently biodegradable (24.5 % degradation after 28 d).
Bioaccumulation
Using the EPISuite BCFBAF program Bioconcentration Factors (BCF) in the range of 3.162 L/kg wet-wt (log BCF = 0.5) and 740.2 L/kg wet-wt (log BCF = 2.869) have been calculated for representative structures of the registered UVCB substance as specified in IUCLID section 1.2 comprising the potential structures available for exposure. Based on these calculated results, a low potential for bioconcentration is to be expected (BCF < 2000). Further, some more factors have been taken into account: In general, absorption of a chemical is possible, if the substance crosses biological membranes. This process requires a substance to be soluble, both in lipid and in water and is also dependent on its molecular weight (substances with molecular weights below 500 are favourable for absorption). According to the composition given in IUCLID section 1.2 about 90 % of the UVCB substance has a molecular weight > 500, ~62 % even > 1000 and hence, the potential to cross biological membranes is very low. Further, the water solubility of the substance is < 1 mg/L (but as the detection limit was 1 mg/L, the water solubility might even be < 0.1 mg/L), which also implies that absorption is presumed to be hindered. In conclusion the substance is expected to be poorly absorbed considering its molecular weight and water solubility.
Transport and distribution
The adsorption coefficient of the UVCB substance was estimated by calculation for the individual constituents of the substance, resulting in a Koc range of 9010 to 1.00E+10 L/kg (Log Koc range of 3.9547 to 18.1711). This is indicative of a high sorption potential onto soil organic matter for the majority of the UVCB substance, which has been expected given the low water solubility.
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