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Description of key information

Acute Toxicity
- oral: LD50 = 1866 mg/kg bw (rat)
- inhalative: LC50 = 20.55 mg/l (8h, rat)
- ip: LD50 = 243 mg/kg bw (mouse)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 866 mg/kg bw

Additional information

In a study, which was in large part equivalent to the methods described in OECD Guideline 401, the LD50 for rats was estimated to be 1866 mg/kg body weight (BASF AG, 1969). During this study, the inhalative acute toxicity was also evaluated, by exposing rats to a vapor generated by 20°C for 8h and to vapor generated by 100°C for 3 and 8 h. The resulting values for lethality were a LC0 of 3.58 mg/l, LC0 of 26.23 and a LC50 of 20.55 mg/l, respectively (BASF AG, 1969). Intraperitoneal injection of mice led to LD50 values of 243 mg/kg body weight (BASF AG, 1969).

Justification for classification or non-classification

Due to the estimated LD50 of 1866 mg/kg bw 2,5,6 -Trimethyl-2 -cyclohexen-1 -on has to be classified harmful.

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