Registration Dossier
Registration Dossier
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EC number: 243-473-0 | CAS number: 20030-30-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- internal BASF method which was in large part similar to OECD Guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,5,6-trimethylcyclohex-2-en-1-one
- EC Number:
- 243-473-0
- EC Name:
- 2,5,6-trimethylcyclohex-2-en-1-one
- Cas Number:
- 20030-30-2
- Molecular formula:
- C9H14O
- IUPAC Name:
- 2,5,6-trimethylcyclohex-2-en-1-one
- Details on test material:
- - Name of test material (as cited in study report): 2,5,6-Trimethyl-2-cyclohexen-1-on = TMCH
- Density: 0.933 g/ml
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: male 156 - 260 g; female 160 - 200 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2%, 20%, 30%
- Amount of vehicle (if gavage): 10 ml - Doses:
- 200, 1600, 2000, 2500, 5000 µl/kg bw (= 186.6, 1492.8, 1866, 2332.5, 4665 mg/kg bw)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and mortality
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 866 mg/kg bw
- Mortality:
- 5000 µl: 17/20 deaths within 24 h; 20/20 within 48 h
2500 µl: 2/20 deaths within 24 h; 18/20 deaths within 48 h; 19/20 within 7 days
2000 µl: 1/20 deaths within 24 h; 11/20 deaths within 48 h; 11/20 deaths within 7 days
1600 µl: 5/20 deaths within 24 h; 5/20 deaths within 48 hours; 5/20 deaths within 7 days
200 µl: 0/20 deaths within 7 days - Clinical signs:
- other: 2000 - 5000 µl/kg bw: - immediately after dosing staggering and high stepping gait, intermittent or accelerated respiration and salivation. - After about 10 min abdominal or lateral positions and almost unconsciousness at 2500 - 5000 µl/kg bw). - After
- Gross pathology:
- - tonic and dilated stomach
- almond odor of bowls - Other findings:
- - Other observations: mouth smeard with blood, in some cases bloody discharge from nose, in some cases anogenital region smeared with blood
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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