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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

- Skin irritation: irritant to rabbit skin (15 min application)
- Eye irritation: not irritating to rabbit eye

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

In a study, which was in large part equivalent to the methods described in OECD Guideline 404, irritant effects to skin were detected. Even after an application time of 15 min prominent erythema at 24 - 72 h and desquamation after 8 days after the application were found (BASF AG, 1969). When 0.5 ml was applied to rabbit eyes, no irritant effects were observed (BASF AG, 1969).

Effects on skin irritation/corrosion: irritating

Justification for classification or non-classification

Due to results obtained in studies, which were in large part similiar to OECD Guidelines, 2,5,6 -Trimethyl-2-cyclohexene-1-one has to be classsified as irritant to skin, but not classified as irritant to eyes.