Alcohols, C12-14

Toxicity to aquatic plants other than algae

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic plants other than algae

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

ECOSAR Program(v1.00)

GLP compliance:

no

Remarks:

not applicable to QSAR models

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: QSAR model

Test type:

other: QSAR model

Water media type:

freshwater

Limit test:

no

Total exposure duration:

30 d

Hardness:

not applicable. QSAR model

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Dissolved oxygen:

not applicable. QSAR model

Salinity:

not applicable. QSAR model

Details on test conditions:

-Name of test material (as cited in study report:Alcohols, C12-14
CAS Number:80206-82-2
SMILES : CCCCCCCCCCCCO
CHEM : Alcohols, C12-14
MOL FOR: C12 H26 O1
MOL WT : 186.34
Log Kow: 4.77 (KowWin estimate)
Wat Sol: 4 mg/L (experimental database)

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

0.704 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Duration:

30 d

Dose descriptor:

NOEC

Effect conc.:

0.427 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Details on results:

A 96 h LC50 value of 0.704 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
The data show the multi-component substances containing alcohols with carbon numbers in the ranges C12-16 to be acutely toxic at concentrations of between 0.03-0.1 mg/L. At these concentrations all the components are likely to have been fully dissolved.
This result signifies that the test substance is expected to be toxic.

A NOEC value of 0.427 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
This result signifies that the test substance is expected to be toxic.

Overview of QSARs estimations onaquatic toxicity of Alcohols, C12-14 to algae and aquatic plants  

Method	Results	Remarks	Reference
QSAR estimate	Green Algae and Aquatic plants, 96-hr EC50 =0.704 mg/L (ppm)  Green Algae and Aquatic plants 30-day, NOEC cited as a ChV value = 0.427 mg/L (ppm)	Reliable with restrictions, QSAR estimated data	ECOSAR Program (v1.00)

 

 

Green Algae and Aquatic plants, 96-hr EC50 =0.704 mg/L (ppm)

Green Algae and Aquatic plants,30-day, NOEC cited as a ChV value = 0.427

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for organic chemicals properties assessment.

Conclusions:

A 96 h LC50 value of 0.704 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants .
The data show the multi-component substances containing alcohols with carbon numbers in the ranges C12-16 to be acutely toxic at concentrations of between 0.03-0.1 mg/L. At these concentrations all the components are likely to have been fully dissolved.
This result signifies that the test substance is expected to be toxic.

A NOEC value of 0.427 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants .
This result signifies that the test substance is expected to be toxic.

Executive summary:

A 96 h LC50 value of 0.704 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants .

The data show the multi-component substances containing alcohols with carbon numbers in the ranges C12-16 to be acutely toxic at concentrations of between 0.03-0.1 mg/L. At these concentrations all the components are likely to have been fully dissolved.

This result signifies that the test substance is expected to be toxic.

A NOEC value of 0.427 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants .

This result signifies that the test substance is expected to be toxic.

 

Description of key information

A 96 h LC50 value of 0.704 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants . 
The data show the multi-component substances containing alcohols with carbon numbers in the ranges C12-16 to be acutely toxic at concentrations of between 0.03-0.1 mg/L. At these concentrations all the components are likely to have been fully dissolved.
This result signifies that the test substance is  expected to be toxic. 
A NOEC value of 0.427 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants . 
This result signifies that the test substance is  expected to be toxic.
The available data for saltwateraquatic plants other than algae are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa

Key value for chemical safety assessment

EC50 for freshwater plants:

0.704 mg/L

EC50 for marine water plants:

0.07 mg/L

EC10 or NOEC for freshwater plants:

0.427 mg/L

EC10 or NOEC for marine water plants:

0.043

Additional information

A 96 h LC50 value of 0.704 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants .

The data show the multi-component substances containing alcohols with carbon numbers in the ranges C12-16 to be acutely toxic at concentrations of between 0.03-0.1 mg/L. At these concentrations all the components are likely to have been fully dissolved.

This result signifies that the test substance is expected to be toxic.

A NOEC value of 0.427 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group and Aquatic plants .

This result signifies that the test substance is expected to be toxic.

The available data for saltwateraquatic plants other than algae are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa