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EC number: 279-420-3 | CAS number: 80206-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Interlaboratory evaluation of a human patch test for the identification of skin irritation potential/hazard
- Author:
- Griffiths, H.A., et al.
- Year:
- 1 997
- Bibliographic source:
- Food and Chemical Toxicology 35:255-260
Materials and methods
- Type of study / information:
- In this inter-laboratory assessment of the human patch test
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- inter-laboratory assessment of the human patch testb using a Hill Top chamber
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexan-1-ol
- EC Number:
- 203-852-3
- EC Name:
- Hexan-1-ol
- Cas Number:
- 111-27-3
- IUPAC Name:
- hexan-1-ol
- Reference substance name:
- 1-Hexanol
- IUPAC Name:
- 1-Hexanol
- Details on test material:
- - Analytical purity: not givenEC Name hexan-1-olCAS Name 1-HexanolCAS Number 111-27-3EC Number 203-852-3Molecular Formula C6H14O
Constituent 1
Constituent 2
Method
- Ethical approval:
- confirmed, but no further information available
- Details on study design:
- Groups of at least 30 volunteers were used for each evaluation at each location, at least 2 locations tested each product. The undiluted material (0.2 ml) was applied to the outer arm using a Hill Top chamber for a period usually of 4 hours. The reaction was assessed at 24, 48 and 72 hours after initiation of the exposure. SDS (sodium dodecyl sulphate) was used as a positive control. If the proportion of the test group reacting to the test material was significantly less that those reacting to the positive control the material was considered as not classifiable as a skin irritant.
- Exposure assessment:
- not specified
Results and discussion
- Results:
- laboratory assessment of the human patch test hexanol gave responses significantly lower than the positive control and results were
similar between laboratories. N-hexanol was therefore not considered as a skin irritant.
Applicant's summary and conclusion
- Conclusions:
- laboratory assessment of the human patch test hexanol gave responses significantly lower than the positive control and results were
similar between laboratories. N-hexanol was therefore not considered as a skin irritant.
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