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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Method: other: in house procedure
GLP compliance:
yes
Test type:
other: LD50
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C12-14
EC Number:
279-420-3
EC Name:
Alcohols, C12-14
Cas Number:
80206-82-2
Molecular formula:
C13H28O
IUPAC Name:
Alcohols, C12-14
Details on test material:
Tradename Lorol Spezial type 70 C12-14 alcohols Type A

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ORGANISMS: Rat (Wistar)
- Source: not reported
- Weight at study initiation: mean weight 190g
- Group size: 10 F
- Controls: no



Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Details on oral exposure:
ADMINISTRATION: Gavage
- Doses: 5 and 10g/kg
- Doses per time period: Single
- Volume administered or concentration: 20 ml/kg constant dose as a solution in olive oil
- Post dose observation period: 14 days

EXAMINATIONS: The animals were observed for mortality and clinical signs.

Doses:
5000 and 10000 mg/kg
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
ADMINISTRATION: Gavage
- Doses: 5 and 10g/kg
- Doses per time period: Single
- Volume administered or concentration: 20 ml/kg constant dose as a solution in olive oil
- Post dose observation period: 14 days

Statistics:
No statistical analysis of the results was carried out in this study.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
No deaths during the study.
Clinical signs:
other: No signs of intoxiciation
Other findings:
NECROPSY FINDINGS: Necropsy not carried out.
POTENTIAL TARGET ORGANS: No indication given.
SEX-SPECIFIC DIFFERENCES: Only females teste

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The rat oral LD50 for this C12-14 alcohol Lorol Spezial type 70 was >10000 mg/kg. There were no signs of intoxication.