Alcohols, C12-14

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

other: published data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

The Aspiration Hazard and Toxicity of a Homologous Series of Alcohols.

Author:

Gerare, H. and Ahlstrom, D.

Year:

1966

Bibliographic source:

Arch. Environ.|Health, Vol. 13, October, 1966.

Reference 2

Reference Type:

review article or handbook

Title:

Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York:

Author:

Clayton, G. D. and F. E. Clayton (eds.).

Year:

1981

Bibliographic source:

John Wiley Sons, 1981-1982., p. 4610

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Method other: lethality by aspiration
Animals were induced to aspirate the test substance placing 0.2 ml of the test substance into the mouth and then closing the nostrils during inspiration.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Hexan-1-ol

EC Number:

203-852-3

EC Name:

Hexan-1-ol

Cas Number:

111-27-3

IUPAC Name:

hexan-1-ol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

other: intratracheal

Vehicle:

unchanged (no vehicle)

Details on exposure:

Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and  then closing the nostrils during inspiration. 

Doses:

0.2 ml

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and  then closing the nostrils during inspiration. 

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

other: lethality by aspiration

Effect level:

0.2 other: ml per animal

Based on:

test mat.

Mortality:

Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and  then closing the nostrils during inspiration.  10/10  animals died immediately.  The cause of death was  suspected to be respiratory or cardiac arrest, or both.

Clinical signs:

The lungs showed small areas of focal pulmonary hemorrhage and edema.

Applicant's summary and conclusion

Conclusions:

Acute Exposure/ Aspiration of 0.2 ml of hexyl alcohol by the rat caused respiratory arrest and instant death. The lungs showed small areas of focal pulmonary hemorrhage and edema.