Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 279-420-3 | CAS number: 80206-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- The Aspiration Hazard and Toxicity of a Homologous Series of Alcohols.
- Author:
- Gerare, H. and Ahlstrom, D.
- Year:
- 1 966
- Bibliographic source:
- Arch. Environ.|Health, Vol. 13, October, 1966.
- Reference Type:
- review article or handbook
- Title:
- Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York:
- Author:
- Clayton, G. D. and F. E. Clayton (eds.).
- Year:
- 1 981
- Bibliographic source:
- John Wiley Sons, 1981-1982., p. 4610
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method other: lethality by aspiration
Animals were induced to aspirate the test substance placing 0.2 ml of the test substance into the mouth and then closing the nostrils during inspiration. - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Hexan-1-ol
- EC Number:
- 203-852-3
- EC Name:
- Hexan-1-ol
- Cas Number:
- 111-27-3
- IUPAC Name:
- hexan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: intratracheal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and then closing the nostrils during inspiration.
- Doses:
- 0.2 ml
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and then closing the nostrils during inspiration.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: lethality by aspiration
- Effect level:
- 0.2 other: ml per animal
- Based on:
- test mat.
- Mortality:
- Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and then closing the nostrils during inspiration. 10/10 animals died immediately. The cause of death was suspected to be respiratory or cardiac arrest, or both.
- Clinical signs:
- The lungs showed small areas of focal pulmonary hemorrhage and edema.
Applicant's summary and conclusion
- Conclusions:
- Acute Exposure/ Aspiration of 0.2 ml of hexyl alcohol by the rat caused respiratory arrest and instant death. The lungs showed small areas of focal pulmonary hemorrhage and edema.
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