3-methylpyrazole

Toxicity to terrestrial arthropods

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to terrestrial arthropods: short-term

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1991-05-23 - 1991 -09-01

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

according to guideline

Guideline:

other: BBA 23-2.1.8 (1990)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Application method:

spray

Analytical monitoring:

no

Vehicle:

yes

Remarks:

water

Test organisms (species):

Poecilus cupreus

Animal group:

Coleoptera (soil-dwelling carabid beetle)

Details on test organisms:

3 male and 3 female animals

Study type:

laboratory study

Limit test:

no

Total exposure duration:

14 d

Post exposure observation period:

no

Test temperature:

17 - 25 °C

Photoperiod and lighting:

16 h/day

Nominal and measured concentrations:

Nominal:
1.944 kg/ha

Reference substance (positive control):

no

Key result

Duration:

14 d

Dose descriptor:

NOEC

Effect conc.:

1 944 g/ha

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

yes

Conclusions:

NOEC: 1.944 kg/ha soil.

Executive summary:

In a 14 day acute contact toxicity study, ground beetles (Poecilus cupreus-Imagines) were exposed to 3-Methylpyrazol administered by contact with soil at an application rate of 1,944 kg/ha soil in accordance with the guideline BBA 23-2.1.8 (1990). Neither mortality nor reduced food consumption were observed.

Reference 2

Endpoint:

toxicity to terrestrial arthropods: short-term

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1991-03-15 - 1991-09-01

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Deviation from guideline: direct feeeding of single honeybees without anesthetization.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 213 (Honeybees, Acute Oral Toxicity Test)

Deviations:

yes

Remarks:

no anesthetization of the honeybees

GLP compliance:

yes (incl. QA statement)

Application method:

oral

Analytical monitoring:

no

Vehicle:

yes

Test organisms (species):

Apis mellifera

Animal group:

Hymenoptera (honeybees)

Study type:

laboratory study

Limit test:

no

Total exposure duration:

24 h

Reference substance (positive control):

yes

Remarks:

Parathionmethyl 575 g/L

Key result

Duration:

24 h

Dose descriptor:

LD50

Effect conc.:

>= 50 - <= 100 µg per animal

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

yes

Conclusions:

The acute oral LD50 of 3-Methylpyrazol to honeybees is 500-1000 mg/kg bw.

Executive summary:

In a 24 hr-acute oral toxicity study, honey bees (Apis mellifera L.) were exposed to 3-Methylpyrazol administered in the feed solution (0.1 ml of 1% solution of 3-Methylpyrazol in water) similar to OECD 213. The LD50 value was 50 - 100 µg a.i./bee. 

Wight of one honey bee: approx. 100 mg according to Spürgin: DIe Honigbiene, Ulmer Verlag, 2008

Based on this body weight the LD50 can be estimated with 50 microg per 100 mg bodyweight - 500 mg per kg bodyweight

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil dwelling arthropods:

1 944 000 mg/kg soil dw