Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
After oral administration of 3-Methylpyrazol to male and female rats the maximal organ burden was determined after 30-60 minutes. Thereafter the substance is quickly eliminated (93-96% after 24 hours) via urine. A slightly increased 14C-activity was observed in all organs. 3-Methylpyrazol crosses the placental barrier.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100

Additional information

One key study with Klimisch score 2 is available. The measured blood concentration of 3 -Methylpyrazole was 0.001 % of the administered dose after 240 minutes. Excretion reached 93 -96% after 24 hours.

Based on the high water solubility of 3 -Methylpyrazole the oral absorption rate was set to 100 %.