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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from U.S Environmental protection Agency report

Data source

Reference
Reference Type:
secondary source
Title:
Investigation of selected Potential environmental contaminants: Nitroaromatics
Author:
Philip H. Howard, Joseph Santodonato, Jitendra Saxna, Judith Malling and Dorothy Greninger
Year:
1976
Bibliographic source:
U.S Environmental protection Agency, June 1976, page no 372

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity of 3'-Nitroacetophenone in rabbits
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3'-nitroacetophenone
EC Number:
204-504-3
EC Name:
3'-nitroacetophenone
Cas Number:
121-89-1
Molecular formula:
C8H7NO3
IUPAC Name:
1-(3-nitrophenyl)ethanone
Constituent 2
Reference substance name:
3-nitroacetophenone
IUPAC Name:
3-nitroacetophenone
Test material form:
solid
Details on test material:
Name of test material (as cited in study report): 3 nitro acetophenone
Molecular formula : C8H7NO3
Molecular weight: 165.147 g/mol
Smiles notation : c1(cc(ccc1)[N+](=O)[O])C(C)=O
InChl : 1S/C8H7NO3/c16(10)73248(57)9(11)12/h25H,1H3
Substance type: Organic
Physical state: Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3'-Nitroacetophenone
- Molecular formula (if other than submission substance): C8H7NO3
- Molecular weight (if other than submission substance): 165 g/mole
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal application
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
3756 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 756 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed.
Mortality:
50 % mortality was observed in treated rabbits at 3756 mg/kg bw after 14 days
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 3756 mg/kg bw when rabbits were treated with 3'-Nitroacetophenone by dermal application.
Executive summary:

In a Acute dermal toxicity study, rabbits were treated with 3'-Nitroacetophenone in the concentration of 3756 mg/kg bw by dermal application. 50 % mortality was observed in treated rabbits at 3756 mg/kg bw after 14 days. Therefore,LD50 was considered to be3756 mg/kg bw when rabbits were treated with 3'-Nitroacetophenone by dermal application.

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