Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-504-3 | CAS number: 121-89-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from U.S Environmental protection Agency report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Investigation of selected Potential environmental contaminants: Nitroaromatics
- Author:
- Philip H. Howard, Joseph Santodonato, Jitendra Saxna, Judith Malling and Dorothy Greninger
- Year:
- 1 976
- Bibliographic source:
- U.S Environmental protection Agency, June 1976, page no 372
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity of 3'-Nitroacetophenone in rabbits
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 3'-nitroacetophenone
- EC Number:
- 204-504-3
- EC Name:
- 3'-nitroacetophenone
- Cas Number:
- 121-89-1
- Molecular formula:
- C8H7NO3
- IUPAC Name:
- 3'-nitroacetophenone
- Reference substance name:
- 3-nitroacetophenone
- IUPAC Name:
- 3-nitroacetophenone
- Test material form:
- solid
- Details on test material:
- Name of test material (as cited in study report): 3 nitro acetophenone
Molecular formula : C8H7NO3
Molecular weight: 165.147 g/mol
Smiles notation : c1(cc(ccc1)[N+](=O)[O])C(C)=O
InChl : 1S/C8H7NO3/c16(10)73248(57)9(11)12/h25H,1H3
Substance type: Organic
Physical state: Solid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3'-Nitroacetophenone
- Molecular formula (if other than submission substance): C8H7NO3
- Molecular weight (if other than submission substance): 165 g/mole
- Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: Dermal application
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 3756 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 756 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed.
- Mortality:
- 50 % mortality was observed in treated rabbits at 3756 mg/kg bw after 14 days
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 3756 mg/kg bw when rabbits were treated with 3'-Nitroacetophenone by dermal application.
- Executive summary:
In a Acute dermal toxicity study, rabbits were treated with 3'-Nitroacetophenone in the concentration of 3756 mg/kg bw by dermal application. 50 % mortality was observed in treated rabbits at 3756 mg/kg bw after 14 days. Therefore,LD50 was considered to be3756 mg/kg bw when rabbits were treated with 3'-Nitroacetophenone by dermal application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
