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Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Handbook.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical
Author:
Michael and Irene Ash
Year:
2004
Bibliographic source:
Handbook of Preservatives, 2004.
Reference Type:
other: authoritative database
Title:
Acute oral toxicity by using test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of the given test chemical in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzoic acid, 2,3,4,5-tetrachloro-6-[[(2,3-dichlorophenyl)amino]carbonyl]-
EC Number:
616-316-2
Cas Number:
76280-91-6
Molecular formula:
C14H5Cl6NO3
IUPAC Name:
Benzoic acid, 2,3,4,5-tetrachloro-6-[[(2,3-dichlorophenyl)amino]carbonyl]-
Details on test material:
Name: Benzoic acid, 2,3,4,5-tetrachloro-6-[[(2,3-dichlorophenyl)amino]carbonyl]-
Common Name: Tecloftalam
InChI: 1S/C14H5Cl6NO3/c15-4-2-1-3-5(8(4)16)21-13(22)6-7(14(23)24)10(18)12(20)11(19)9(6)17/h1-3H,(H,21,22)(H,23,24)
Smiles: c1(c(c(c(Cl)c(c1Cl)Cl)Cl)C(O)=O)C(Nc1c(c(ccc1)Cl)Cl)=O
- Molecular formula (if other than submission substance):C14H5Cl6NO3
- Molecular weight (if other than submission substance):447.915 g/mol
- Substance type:Organic
- Physical state:Colorless Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
2340 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 340 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed.
Mortality:
50% mortality was observed at 2340 mg/kg.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 was considered to be 2340 mg/kg bw, when male rat was treated with the given test chemical via oral route.
Executive summary:

Acute oral toxicity test was conducted using the given test chemical in male rat at the concentration of 2340 mg/kg bw. 50% mortality was observed at 2340 mg/kg bw.

Hence, the LD50 was considered to be 2340 mg/kg bw, when male rat was treated with test chemical via oral route.