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Registration Dossier
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EC number: 214-901-3 | CAS number: 1208-67-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Safety Assessment of the given test chemical
- Author:
- Bergfeld et al.
- Year:
- 2 011
- Bibliographic source:
- International Journal of Toxicology
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 005
- Bibliographic source:
- United Nations Environmental Programme (UNEP) 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity of the given test chemical in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium cumenesulphonate
- EC Number:
- 248-983-7
- EC Name:
- Sodium cumenesulphonate
- Cas Number:
- 28348-53-0
- Molecular formula:
- C9H12O3S.Na
- IUPAC Name:
- sodium 2-phenylpropane-2-sulfonate
- Details on test material:
- - IUPAC Name: Sodium cumenesulphonate
- Smiles : c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
- Molecular formula :C9H12O3S.Na
- Molecular weight: 223.2468 g/mole
- Substance type:Organic
- Physical state:Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 2000 mg/kg bw in treated animals.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal toxicity dose (LD50) value was considered to be >2000 mg/kg bw, when rabbits were treated with the given test chemical by dermal application.
- Executive summary:
Acute dermal toxicity study was conducted using the given test chemical in rabbits at the dose concentration of 2000 mg/kg bw.
Animals were observed for mortality. No mortality was observed at 2000 mg/kg bw in treated animals.
Hence, the LD50 value was considered to be >2000 mg/kg bw, when rabbits were treated with the given test chemical by dermal application.
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