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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute toxicity: Oral

LD50 was estimated to be 790 mg/kg bw when rat were orally exposed with 2,3-dimethylphenol.

Acute toxicity: Inhalation

LD50 was considered to be > 85.5 mg/m3when Fischer 344 male rat were exposed to saturated vapors of 2,3-dimethylphenol for 4 h.

Acute toxicity: dermal

LD50 was estimated to be 987 mg/kg bw when Vienna White male and female rabbit were dermally exposed with 2,3-dimethylphenol.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
790 mg/kg bw
Quality of whole database:
Data is from Registry of Toxic Effects of Chemical Substances (RTECS) Database

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
85.5 mg/m³ air
Quality of whole database:
Data is from NTRL report

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
987 mg/kg bw
Quality of whole database:
Data is Klinisch 2 and from OECD QSAR toolbox

Additional information

Acute oral toxicity:

In different studies, 2,3-dimethylphenol has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in mice and rats for 2,3-dimethylphenol. The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In a prediction done by SSS (2017) using the Danish (Q)SAR with log kow as the primary descriptor, the acute oral toxicity was estimated for 2,3-dimethylphenol. The LD50 was estimated to be 790 mg/kg bw when rat were orally exposed with 2,3-dimethylphenol.

In another prediction done by SSS (2017) using the Danish (Q)SAR with log kow as the primary descriptor, the acute oral toxicity was estimated for 2,3-dimethylphenol. The LD50 was estimated to be 660 mg/kg bw when mice were orally exposed with 2,3-dimethylphenol.

Also further supported experimental study given by RTECS (Registry of Toxic Effects of Chemical Substances, 2016), rat were treated with 2,3-dimethylphenol orally. 50 % mortality were observed in treated rat at 562 mg/kg bw. Therefore, LD50 was considered to be 562 mg/kg bw when rats were treated with 2,3-dimethylphenol orally.

This further supported by experimental study given by RTECS (Registry of Toxic Effects of Chemical Substances, 2016), Mice were treated with 2,3-dimethylphenol orally. 50 % mortality were observed in treated mice at 302 mg/kg bw. Therefore, LD50 was considered to be 302 mg/kg bw when mice were treated with 2,3-dimethylphenol orally.

Further supported by study summarized by European Food Safety Authority (EFSA) (EFSA Journal 2011; 9(5):1990), rat were treated with 2,3-dimethylphenol in the concentration of 5000 mg/kg bw. 50 % mortality was observed in treated rat at 5000 mg/kg bw. Therefore, LD50 was considered to be < 5000 mg/kg bw when rat were treated with 2,3-dimethylphenol orally.

Thus, based on the above studies and predictions on 2,3-dimethylphenol, it can be concluded that LD50 value is less than 2000 mg/kg bw. Thus comparing this value with the criteria of CLP regulation, 2,3-dimethylphenol can be classified under “Category IV” for acute oral toxicity.

Acute inhalation toxicity:

In a study, 2,3-dimethylphenol has been investigated for acute inhalation toxicity to a greater or lesser extent. Study based on in vivo experiments in rodents, i.e. most commonly in rats for 2,3-dimethylphenol.

In a experimental study conducted by Kinkeadet al(National Technical Information Service. AAMRL-TR-87-021, APRIL 1987), Fischer 344 male rat were exposed to saturated vapors of 2,3-dimethylphenol for 4 h in a clear, 120-L ptexiglas chamber. No mortality was observed in treated male rat at 85.5 mg/m3. No effect on body weight gain and no gross lesions were observed in treated rats as compared to control. Therefore, LD50 was considered to be > 85.5 mg/m3when Fischer 344 male rat were exposed to saturated vapors of 2,3-dimethylphenol for 4 h.

Thus, based on the above studies and predictions on 2,3-dimethylphenol, it can be concluded that LD50 value is less than 20 mg/L. Thus, comparing this value with the criteria of CLP regulation, 2,3-dimethylphenol can be Not classified as acute inhalation toxicity.

Acute dermal toxicity:

In different studies, 2,3-dimethylphenol has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for 2,3-dimethylphenol along with the study available on structurally similar read across substance p-Cresol (CAS no 106-44-5) and o-Cresol (CAS 95-48-7). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 2,3-dimethylphenol. The LD50 was estimated to be 987 mg/kg bw when Vienna White male and female rabbit were dermally exposed with 2,3-dimethylphenol.

In another experimental study given by RTECS (Registry of Toxic Effects of Chemical Substances, 2016), mice were treated with 2,3-dimethylphenol dermally. 50 % mortality were observed in treated mice at 920 mg/kg bw. Therefore, LD50 was considered to be 920 mg/kg bw when mice were treated with 2,3-dimethylphenol dermally.

Also further supported by experimental study given by RTECS (Registry of Toxic Effects of Chemical Substances, 2016), rabbits were treated with 2,3-dimethylphenol dermally. 50 % mortality were observed in treated rabbits at 1040 mg/kg bw. Therefore, LD50 was considered to be 1040 mg/kg bw when rabbits were treated with 2,3-dimethylphenol dermally.

This is further supported by experimental study summarize by Cosmetics Ingredient Expert Review Panel (International Journal of Toxicology; Volume: 25 issue: 1_suppl, page(s): 29-127; 2006) on structurally similar read across substance p-Cresol (CAS no 106-44-5), rabbits were treated with p-Cresol applied on rabbits in the concentration of 300 mg/kg for 24 hours. 50 % Mortality was observed in treated rabbits. Therefore, LD50 was reported to be 300mg /kg bw when rabbits were treated with p-Cresol by dermal application for 24 hours.

Further supported by experimental study summarize by Cosmetics Ingredient Expert Review Panel (International Journal of Toxicology; Volume: 25 issue: 1_suppl, page(s): 29-127; 2006) on structurally similar read across substance o-Cresol (CAS 95-48-7), rabbits were treated with o-Cresol applied on rabbits in the concentration of 890 mg/kg. 50 % Mortality was observed in treated rabbits at 890 mg/kg bw. Therefore, LD50 was considered to be 890 mg /kg bw when rabbits were treated with o-Cresol by dermal application.

Thus, based on the above studies and predictions on 2,3-dimethylphenol and its read across substances, it can be concluded that LD50 value is < 1000 mg/kg bw. Thus comparing this value with the criteria of CLP regulation, 2,3-dimethylphenol can be classified under “Category III” for acute dermal toxicity.

Justification for classification or non-classification

Based on the above studies and predictions on 2,3-dimethylphenol, it can be concluded that 2,3-dimethylphenol can be classified under “Category IV” for acute oral toxicity and “Category III” for acute dermal toxicity and not Classified for acute Inhalation toxicity .