Registration Dossier
Registration Dossier
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EC number: 212-338-8 | CAS number: 791-28-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; nominal atmosphere concentration); however, this test design is unsuitable for solids
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- nominal determination of the test atmosphere by rewighing
- GLP compliance:
- no
- Test type:
- other: Inhalation hazard test (IHT)
- Limit test:
- yes
Test material
- Reference substance name:
- Triphenylphosphine oxide
- EC Number:
- 212-338-8
- EC Name:
- Triphenylphosphine oxide
- Cas Number:
- 791-28-6
- Molecular formula:
- C18H15OP
- IUPAC Name:
- triphenylphosphine oxide
- Details on test material:
- - Name of test material (as cited in study report): Triphenylphosphinoxid
- Physical state: crystalline powder
- Purity: pure p.a.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: males: 170 g, females 164.5 g
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Rats exposed for 8 h to a dust atmosphere.
Dust was generated by pumping 200 l/h dry air (no CO2) through the powder column of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. Temperature in the exposure chamber was room temperature. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- not applicable
- No. of animals per sex per dose:
- 12
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Exp. duration:
- 8 h
- Remarks on result:
- other: 0/12 animals died after 8 hour of exposure to the test atmosphere. Due to the design of atmosphere generation, no exposure to the test substance is to exspected.
- Mortality:
- 0/12 animals died
- Clinical signs:
- other: No symptoms were observed.
- Gross pathology:
- No findings were reported.
Any other information on results incl. tables
Due to the design of atmosphere generation, no exposure to the test substance is to exspected.
Applicant's summary and conclusion
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